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Anti-Diabetic Properties Observed in Brain Chemical That Regulates Mood
The findings by the researchers at the University of Texas Southwestern Medical Center also offer a potential explanation for why individuals prescribed certain kinds of anti-psychotic drugs that affect serotonin signalling sometimes have problems with their metabolism, including weight gain and the development of diabetes.
"In this paper, we describe a circuit in the brain that may explain the anti-diabetic actions of serotonin-receptor signalling," said Dr Joel Elmquist, professor of internal medicine and pharmacology at UT Southwestern and senior author of the study.
"This discovery tells us that drugs that affect serotonin action can have anti-diabetic actions independent of body weight and feeding," he added.
For the current study, the researchers engineered a mouse model in which the expression of a serotonin receptor called 5-hydroxytryptamine 2C was blocked throughout the entire body.
Without functioning receptors, the mice developed insulin resistance in their livers.
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