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Another Necessary Step in Memory Formation Identified
The researchers say that, together with the results of previous studies, the new findings provide a better understanding of the process of memory formation and storage in the human brain.
In their study report, the researchers point out that the formation of memory to sensory information on the world-new sounds, tastes, sights, and smells-is vital for animal survival.
They say that very little of this information becomes short-term memory, and that only a small part of the information that becomes short-term memory ultimately becomes long-term and stabilized memory.
Previous studies led by Prof. Kobi Rosenblum found an elevation in the expression of the protein PSD-95 to be necessary for the formation of long-term memory.
The present study aimed to find out whether another molecular process - the addition of a phosphor molecule to the NMDA receptor protein (phosphorylation) - is necessary too.
Earlier studies have proven that changes in the NMDA receptor can adjust the neuronal network in the brain, and that during a learning process this receptor undergoes increased phosphorylation.
Before the present research, none of the studies had proved that the increase in phosphorylation of the NMDA is necessary for the process, and that the process would not occur without it.
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