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Alcohol-induced Congenital Heart Defects in Mice can be Prevented by Folate
Researchers at the University of South Florida College of Medicine and All Children's Hospital report that the protection was afforded only when folate was administered very early in pregnancy and before the alcohol exposure.
The dose that best protected against heart defects in mice was considerably higher than the current dietary recommendation of 400 micrograms (0.4 milligrams) daily for women of child-bearing age.hile more research is needed, the study has implications for re-evaluating folate supplementation levels during early pregnancy, said principal investigator Dr. Kersti Linask.
"Congenital heart defects can occur in the developing embryo at a time when women typically do not even know they are pregnant - 16 to 18 days following conception. They may have been drinking alcohol or using prescription drugs without realizing this could be affecting embryonic development," said Linask.
"We found that we could prevent alcohol-associated defects from arising in the mice-provided folate was given in relatively high concentrations very early in pregnancy around conception," he added.
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