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Home » Cancer News

Aggressive Breast Cancers Linked to Dense Tissue

by Rajashri on August 25, 2008 at 5:10 PM Cancer News

Breast cancer cells grown in dense tissues promote aggressive cancers, a new study from Vanderbilt-Ingram Cancer Centre has found.

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The research team found that breast cancer cells grown in dense, rigid surroundings increased their invasive activities. Women with increased breast density on mammograms have an increased risk for both developing breast cancer and having breast cancers with invasive characteristics.

"Our study shows that if you have a dense, rigid matrix, the cells will be more aggressive and invasive; it''s a direct effect," said Alissa Weaver, M.D., Ph.D., assistant professor of Cancer Biology and lead author of the study.

The team led by Weaver focussed their study over invadopodia � the finger-like protrusions that a cancer cell uses to drill holes in the extracellular matrix. These structures are believed to be important for cancer invasion.

"If you have enough invadopodia, over time they''ll make large holes that cells can move through to invade and metastasize," said Weaver.

They found that breast cancer cells cultured on a denser � and thus, more rigid � matrix had a greater number of active invadopodia than breast cancer cells cultured on a less dense matrix.

"We thought that more ''stuff'' for the cells to get through was going to make it harder, so we expected to see less matrix degradation, but instead we found this interesting effect where cells actually sense the rigidity and degrade more," said Weaver.

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Aggressive Breast Cancers Linked to Dense Tissue

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