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Age Greatly Impacts Patients' Ability to Repair Arteries
According to the American Vascular Association (AVA) Resident Research Prize Paper, presented at the 62nd Annual Meeting of the Society for Vascular Surgery, older patients also may have less ability to repair of vessels and arteries after acute injury, similar to other effects of aging.
Study author and Resident Research Prize recipient Tormod S. Westvik, MD, a resident at the Yale University School of Medicine, New Haven, Conn., described how researchers created a model mimicking severe leg ischemia, to examine the effects of age and whether it depresses the regeneration of blood vessels and arteries in severe acute limb ischemia.
Dr. Westvik explained in the lab 15 young adult (three months) and 20 aged (18 months) mice underwent right common iliac artery and vein ligation and transection. Data were collected on days 0, 7 and 14. After severe hindlimb ischemia, both groups of mice had a similar degree of decreased perfusion and all became ischemic. Older mice had a significantly impaired arteriogenesis and functional recovery after 14 days. Aged mice also had increased capillary density and endiothelial progenitor cell numbers compared to young mice, but diminished collateral supply to the ischemic limb.
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