This work is of great interest since it could herald a new approach in the treatment of type 2 diabetes and obesity. "Recently, two classes of drugs exploiting the properties of the hormone GLP-1 have been marketed for the treatment of type 2 diabetes. The first strategy aims to increase the blood levels of GLP-1 by limiting its degradation in the body. The second is to mimic the effects of GLP-1 using drugs activating the GLP-1 receptor (GLP-1R) ", explains Charles Thomas, first author of the study. In this study, the authors propose a third therapeutic option based on increasing GLP-1 secretion via administration of TGR5 agonist therapy. The results obtained by the authors are even more spectacular since in addition to stimulating the secretion of GLP-1, INT-777 activation of TGR5 in other tissues leads to an increase in energy expenditure responsible for a reduction in fat mass and obesity.
Source-Eurekalert
ARU