Rosacea patients also had high levels of enzymes called stratum corneum tryptic enzymes (SCTE). These enzymes turned the precursor into the disease-causing peptide.
The inflammation in the skin of the mice increased when the researches injected them with cathelicidin peptides, indicating that these abnormalities can cause the disease.
"Too much SCTE and too much cathelicidin leads to the abnormal peptides that cause the symptoms of this disease. Antibiotics tend to alleviate the symptoms of rosacea in patients because some of them work to inhibit these enzymes. Our findings may modify the therapeutic approach to treating rosacea, since bacteria aren't the right target," Gallo said.
Source-ANI
LIN/J