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Abiraterone Proves Effective Against Prostate Cancer in Continuing Clinical Trials

by Gopalan on  July 22, 2008 at 9:22 AM Cancer News   - G J E 4
Abiraterone Proves Effective Against Prostate Cancer in Continuing Clinical Trials
Abiraterone, the new prostate cancer drug discovered by British researchers, is showing considerable promise. The pill could be available in the market in three years, they hope.
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Scientists at the Royal Marsden Hospital in South-West London are bubbling with confidence that their discovery could turn out to be a wonder drug.

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Tumours shrank in up to 80 per cent of patients treated. There were also dramatic" falls in levels of prostate-specific antigens - which indicate the severity of prostate cancer. Similar results have been observed in second-phase trials involving about 250 men, details of which have yet to be published.

Dr Johann de Bono, the lead researcher on the study, said: "Patients in this study have been monitored for up to two-and-a-half years and, with continued use of abiraterone, were able to control their disease with few side effects."

They had very aggressive prostate cancer, which is exceptionally difficult to treat and almost always fatal.

And they were able to do so with just four pills a day. The drug works even if the cancer has spread beyond the prostate, such as to the bone.

"We hope that abiraterone will eventually offer them real hope of an effective way of managing their condition and prolonging their lives. My vision is to make chemotherapy obsolete," Bono said.

Current treatment options for prostate cancer include watchful waiting, surgery, chemotherapy, radiation, or hormonal therapy. Male hormones such as testosterone are produced mainly in the testes, but are also produced by the adrenal gland and elsewhere in the body. These hormones can stimulate prostate cancer cells to grow, so the first treatment option for all men with prostate cancer that has spread, is to use chemical suppressants or surgery to inhibit testicular synthesis of male hormones.

However, this treatment does not block the production of male hormones elsewhere in the body. Abiraterone inhibits an enzyme called CYP450c17, which is critical to the production of the male hormones — not only in the testes, but also at other sources.

At the European Society for Medical Oncology Conference Lugano 2007, it was reported that he new drug reduced prostate-specific antigen (PSA) levels and also resulted in tumor shrinkage. Decline in PSA levels was accompanied by evidence of tumor shrinkage on scans, drops in circulating tumor-cell counts, and improvements in symptoms, they noted.

Generally when the hormone therapy fails people turn to chemotherapy, which can have severe side-effects such as nausea, pain, malnutrition, haemorrhages and hair loss.

Many patients also have radiotherapy, to reduce associated pain in the bones. This can be dangerous too, damaging organs and leaving patients exhausted and with little quality of life. Abiraterone seems to offer a way out.

John Neate, chief executive of the Prostate Cancer Charity, said: 'This is an exciting development which has been eagerly anticipated. Advanced prostate cancer is very difficult to treat as, after time, it stops responding to conventional ways of controlling the male hormone.

'We look forward to the results of the larger trials already under way or being planned for this drug to prove its potential effectiveness.'

As the drug is newly in development, it is not yet known how many years' extra survival it can bring. But patients on the trial have so far lived longer than the estimated 12 or 18 months.

Abiraterone is now being used in a 1,200-patient international study, including at ten sites across the UK. If it is licensed as expected in 2011, it will have to await approval by the rationing watchdog NICE before it is made freely available across the NHS.

Drugs usually go through three phases of clinical trials before pharmaceutical companies apply for a licence to make them more widely available. This is to prove their safety and effectiveness in ever-larger groups of patients.

Small trials alone may not be enough to show up side-effects that emerge during much larger studies.

Dr de Bono describes prostate cancer as the 'Cinderella cancer' because it receives just a quarter of the funding of breast cancer - Ģ10million against Ģ40million last year - even though it kills just as many people.

Source: Medindia
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My father and I living in Indonesia, He have prostate cancer, and need Abiraterone immediately. Let me know when and where available ? I would be happy if i can see my father in good condition. Much appreciated for your prompt reply
susan_ind Tuesday, July 13, 2010
I would like to get Abiraterone for my father. Has somebody heard anything about when are they going to make it public? My father and many people are running out of time and we need this medicine ASAP. Meanwhile I found this petition on internet. Please sing it and spread the word. Maybe they can speed up the process of approving it. Please let us know if anyone has additional information about Abiraterone approval.

http://gopetition.com/petitions/ abiraterone-acetate-for-stage-iv -prostate-cancer/sign.html

cfuentes Tuesday, June 8, 2010
I have been battling prostate cancer for the past seven years. I have had all the usual treatments like hormone and radiation but it has proved to no avail.Since I have been accepted into a trial in January 2010, my PSA has halved, and three major tumors have begun to shrink. The sooner this drug is made available worldwide more lives will be saved
peterv Tuesday, May 11, 2010
I am a 66 year old man and have Prostate Cancer. I need to get in touch with Dr. Johann De Bono, who has discovered a new drug called Abiraterone.
carolandkishaenterprises Monday, May 3, 2010

My father living in Dhaka, Bangladesh. He was diagnosed with advanced prostate cancer with bone metastasis in January2008. At his age of 70 Hormone therapy and radiation therapy was used for a year and half. His PSA is continuously rising for the last 8/9 months.Now he cannot walk or getup from bed. We looking out for alternate treatment for him. Abirateron can give him and the whole family hope. Is it possible for him to join and attend a clinical trial with abirateron in Dhaka? His doctor here can treat him with abirateron and get result?

Looking forward to your reply,

Regards

Ayazul Tuesday, March 23, 2010
My Dad has prostate cancer and it has spread to his bones. He is in pain and would love to be involved in a clinical trial of abiraterone. Is there any way for him to be involved in a trial? He lives in California, but he could travel to receive treatment if necessary. Please let us know. Any information would be greatly appreciated. Melissa
turner Wednesday, December 16, 2009
I was diagnosed as having prostate cancer, I live in California, Los Angeles, how do I get into the trial?
wole588 Saturday, August 22, 2009
I have advanced prostate cancer, PSA rising after initial hormone therapy, I live in SA and would like to know how I can get onto the trials
Augustinus Tuesday, August 11, 2009
Hi, my father has had prostate cancer for 3 years and has been treated with hormone therapy for at least a year, but his PSA has been continuing to elevate. Could he be eligible for the trial, his doctor is the one who told him about the drug? Or is it possible to purchase the drug? Looking forward to hearing from you.
kimberlee Monday, June 8, 2009
hi, my father has been diagnosed with prostate cancer at 2002 when he was 57 years old. and his PAS has been cotiously rising in the recent years accompany with the whole body pain. Is there any chances that he can join the trial system? Thank you and I look forward to hearing from you
shadowyuer Sunday, April 12, 2009

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