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A Rose By Any Other Name May Not Smell Sweet Anymore!
They observed that the aldehyde molecules that could stretch to their greatest length triggered strong activity in the OSNs, but those whose carbon chains were constrained into a U shape blocked the receptor and left the cell unable to sense octanal.
"Conformationally constrained odorants were more selective in the number of OSNs they activated. The results indicate that these odorant molecules might be able to alter fragrance mixture odors in two ways: by muting the activity of flexible odorants present in a mixture and by activating a smaller subset of OSNs than chemically related flexible odorants. This would produce a different olfactory code signature," Professor Ryan said.
Given that olfactory receptors belong to the G-protein coupled receptor (GPCR) class of proteins-a family of molecules found in cell membranes throughout the body that are used by many commercial pharmaceuticals-Professor Ryan believes that his team's findings could also have applications to GPCR drug design also.
A research article on the study has been published by the journal Chemistry and Biology.
Source-ANI
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