Alfie has gone through a long chain of problems in his brief life. He was born blind, with severe disabilities, including learning difficulties. He continues to suffer from stomach problems, and is on several drugs to help his body to absorb nutrients. He goes through fits sparked by high temperatures and metabolic problems.
Doctors have stated that the extra strand of material in his seventh chromosome is the cause for his health problems. They are not sure whether the condition will sort itself out as he grows older or even whether he will live long enough to see it sorted out.