A Promising Live Vaccine Against Tuberculosis Enters Trial in Germany

by Hannah Punitha on  September 14, 2008 at 6:59 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

 A Promising Live Vaccine Against Tuberculosis Enters Trial in Germany
A promising live vaccine against tuberculosis has begun safety testing on volunteers in the first phase of clinical trials in Neuss, Germany.

The vaccine called 'VPM1002' has proved to be extremely effective and safe in animal models thus far.

"This good protection now has to be proven in humans for the vaccine to be ready for the final approval," says the Chief Executive Officer of Vakzine Projekt Management GmbH (VPM), Bernd Eisele.

The vaccine is based on a highly safe vaccine that was introduced in 1921, but has been genetically developed to an extent where it is significantly more effective at preventing infection with tuberculosis bacteria than its predecessor.

"The new vaccine is based on the most administered live-vaccine worldwide: Bacille Calmette-Guérin (BCG). However, BCG often fails to display effects anymore. We wanted to sharpen the blunted weapon that is BCG once again," said Stefan H.E. Kaufmann, Founding Director of the Department of Immunology of the Max Planck.

As to how that fate was achieved, Leander Grode, Project Manager at VPM, said: "The weakened vaccine was genetically modified in such a way to ensure that it is no longer able to hide from the human immune system and even stimulates the body's own defences now."

For that a gene of a different bacterium, Listeria, was inserted into the vaccine, added the researcher.

"Macrophages of the human immune system take up the vaccine immediately. There it ends up in phagosomes. Due to the genetic modification the bacteria can leave the phagosomes and are then present in the middle of the immune cell - this alarms the rest of the immune system, which is then armed to repel real tuberculosis pathogens," said Grode.

Source: ANI
SPH

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Tuberculosis Tracheostomy Pleural Effusion Silicosis Screening Tests for Tuberculosis Fever Cough Symptom Evaluation Diet in Tuberculosis Stomach Tuberculosis Extra Pulmonary Tuberculosis 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

Advertisement

News Category

News Archive