Conn's Syndrome

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Other Names :  

Primary Hyperaldosteronism

What is Conn's Syndrome ?  

Conn's syndrome is a disease caused by increased secretion of the hormone aldosterone from the adrenal glands.

Cause(s) :  
  • Bilateral or unilateral adrenal Hyperplasia
  • Adrenal adenoma
  • Familial hyperaldosteronism - Types I and II
  • Unilateral adrenocortical carcinoma
Symptoms :  
  • High blood pressure
  • Low levels of potassium
  • Low blood pH levels
  • Fatigue
  • Cramping
  • Chronic headaches
  • Palpitations
  • Myalgia, muscle weakness or numbness
  • Polydipsia (excessive thirst) and polyuria (increased urination) may be present
  • Patients with long-standing hypertension may show the presence of cardiac and neurological problems.
Diagnosis and Tests :  
    Clinical Examination
  • PAC to PRA ratio: Ratio of Plasma aldosterone
  • Concentration to plasma renin activity
  • Captopril suppression test
  • 24-hour urinary excretion of aldosterone test
  • Saline suppression test
  • CT Scan
Specialist to consult :  Endocrinology

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