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ZyGEM to Distribute PicoPlex(TM) Single-Cell Whole Genome Amplification Kits From Rubicon Genomics in New Zealand and Australia

Saturday, January 30, 2010 Genetics & Stem Cells News J E 4
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ANN ARBOR, Mich., Jan. 29 Rubicon Genomics, Inc., a developer of pre-analytical amplification products that enable more comprehensive genetic analysis of clinical and research samples, announced today that it has reached agreement with ZyGEM to non-exclusively market Rubicon's PicoPlex(TM) single-cell amplification kits in Australia and New Zealand.

"This agreement with ZyGEM represents another major step in the adoption of Rubicon's pre-analytical amplification kits in the global marketplace. Rubicon's technology is capable of performing rapid amplification of nucleic acids from a wide variety of sample types easily and with excellent fidelity," said James Koziarz, President and CEO of Rubicon Genomics.

"Since its introduction in July of 2009, interest in PicoPlex kits in the research and commercial markets has been strong. The PicoPlex technology nicely complements ZyGEM's advanced DNA extraction products and we are looking forward to bringing this cutting-edge technology to the markets we serve in Australia and New Zealand," said Paul Kinnon, CEO of ZyGEM.

With PicoPlex technology, the same amount of genomic data for analysis can be obtained from a single human cell or from 10,000 cells, with minimal background. In a simple three-step, three-hour process, single cells can be lysed and the DNA amplified one million-fold. The amplified DNA can be analyzed using qPCR, microarrays and next-generation sequencing instruments for either research or diagnostic applications. Other whole genome amplification kits based on PCR or multiple displacement amplification inconsistently amplify single cells, with unpredictable locus and allele dropouts. In contrast, PicoPlex delivers amplified total DNA from single cells that reproducibly represents genomic sequences without allele dropouts.

PicoPlex has become the leading method for amplifying single cells for pre-implantation genetic diagnostics and screening (PGD/PGS) of human embryos, and it is expected to displace current technologies for amplifying genomic DNA from circulating tumor cells, tumor tissue, stem cells and forensic samples. The PicoPlex technology is one of a series of new amplification technologies being introduced into the nucleic acid testing market by Rubicon Genomics.

This new agreement follows a 2009 agreement to incorporate ZyGEM's advanced enzymatic nucleic acid extraction technology into Rubicon's pre-analytical platform products designed to significantly improve the performance of DNA and RNA analytical instruments.

About Rubicon Genomics

Rubicon is a pre-analytical platform company that commercializes reagents and kits to increase the analytical and clinical performance of instrument platforms including qPCR, microarrays, and next-generation sequencing. Rubicon kits amplify small clinical samples into large amounts of pure DNA with uniform concentration and molecular weight that increase the sensitivity, specificity, and reproducibility of analysis in research and diagnostic applications, including single cells, formalin-fixed tissue and plasma. Rubicon sells licenses and kits to the clinical markets, including pre-implantation and prenatal testing, cancer testing, and diagnostic manufacturing. For more information and to contact Rubicon, visit www.rubicongenomics.com.

About ZyGEM

ZyGEM Corporation Limited is a rapidly growing biotechnology company with a range of innovative enzyme-based products and technologies based on the company's exclusive collection of microorganisms from extreme environments. ZyGEM's technology has significant competitive advantages over existing methods and has potential applications in a number of sizeable global markets. ZyGEM currently produces DNA and RNA extraction and detection products, molecular biology enzymes and individual enzymes and diagnostics, serving life sciences customers in basic research, forensics, clinical diagnostics and agriculture. ZyGEM has facilities in New Zealand and the U.S.A. For more information, visit www.zygem.com.

Contacts: Rubicon Genomics ZyGEM Jim Koziarz Corporate: Media: President & CEO Paul Kinnon Barbara Lindheim +1 847 780-4410 President & CEO BioCom Partners jkoziarz@midwestvp.com +1 858 720-8333 +1 212 918-4650

SOURCE Rubicon Genomics, Inc.
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