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Rib-X Pharmaceuticals, Inc. Appoints Tony Zook of MedImmune to Board of Directors

Thursday, September 17, 2009 General News J E 4
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NEW HAVEN, Conn., Sept. 16 Rib-X Pharmaceuticals, Inc., a company focused on the discovery, development and commercialization of novel drugs for the treatment of multi-antibiotic resistant infections, today announced that Tony Zook has been appointed to the Company's Board of Directors, succeeding Joseph Amprey, MD, Ph.D.



Mr. Zook is President of MedImmune, Chief Executive Officer of AstraZeneca North America, and Executive Vice President of Global Marketing AstraZeneca. MedImmune was acquired by AstraZeneca in June 2007. As Chief Executive Officer of AstraZeneca North America, Mr. Zook oversees AstraZeneca's business in the region, including MedImmune, the AstraZeneca US Business and the AstraZeneca Canadian Business.



A seasoned executive with more than twenty five years of experience in the pharmaceutical industry, Mr. Zook has been CEO of AstraZeneca US since 2006. He has held various sales and marketing positions in the organization, most recently serving as senior vice president for commercial operations. In that role, Zook was responsible for the company's marketing and sales organizations throughout the US. Mr. Zook joined AstraZeneca USA in 1997 and began his career in 1983 at Berlex Laboratories, where he held both sales and marketing positions.



Mr. Zook earned an associate's degree in chemical engineering from Pennsylvania State University and a bachelor's degree in biology from Frostburg University. He is a member of the board for First State Innovation, the Pennsylvania Division of the American Cancer Society and a member of the Board of Trustees for the Healthcare Leadership Council.



"As the most recent appointment to the Rib-X board, we are looking forward to working with Tony during this exciting time in the company's growth," said Dr. Susan Froshauer, President and Chief Executive Officer, Rib-X. "Tony brings years of sales and marketing experience to his new role and we believe his insight will be extremely helpful as our compounds continue to move toward commercialization."



About Rib-X Pharmaceuticals, Inc.



Rib-X Pharmaceuticals, Inc. is a product-driven small molecule drug discovery and development company focused on the structure-based design of new classes of antibiotics. The Company's underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in protein synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome. The Company's integrated research strategy, which combines state-of-the-art, proprietary computational analysis, X-ray crystallography, medicinal chemistry, microbiology and biochemistry, allows it to rapidly synthesize new agents designed to avoid typical antibiotic resistance mechanisms. Rib-X's iterative intelligent engine has yielded several distinctive new antibiotics, including radezolid, that can be used for the treatment of either community- or hospital-acquired infections. Rib-X has successfully completed Phase 2 trials with delafloxacin (RX-3341), a broad-spectrum fluoroquinolone with potent activity against quinolone-resistant Gram-positive bacteria, including MRSA. Radezolid (RX-1741), an oxazolidinone that was discovered at Rib-X as an oral/IV agent for treatment of serious Gram-positive infections, has completed two Phase 2 trials. The Rx-04 discovery program is developing novel classes of antibiotics active against multi-drug resistant Gram-negative bacteria, and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus, multidrug-resistant Streptococcus pneumoniae and S. pyogenes. Both delafloxacin and radezolid are currently in late-stage clinical trials.





For further information please contact: Media: Irma Gomez-Dib FD Life Sciences Tel: 212-850-5761 irma.gomez-dib@fd.com Investors: John Capodanno FD Life Sciences Tel: 212-850-5705 John.capodanno@fd.com

SOURCE Rib-X Pharmaceuticals, Inc.
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