- Studies Conducted at INRA-Agroparistech Laboratory Under Pr. DanielTome's Supervision and Published* in November 2009, in the Official Journalof the International Bone and Mineral Society "Bone", Reveal new Benefits forPeptan(TM) in Osteoporosis Prevention
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In response to consumer concerns regarding long-term bone health,Rousselot has carried out, for several years now, many studies to demonstratethat an oral intake of Peptan(TM) may have a positive impact on osteoporosis.
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Bone is a living dynamic metabolic system that relies on a maintainedbalance between bone formation and bone resorption. Cells called osteoblastsmake bone while cells called osteoclasts resorb it. An imbalance may lead toosteoporosis, a condition where the density and quality of bone is reduced.
Researchers conducted in vitro studies, and highlighted that Peptan(TM)in bone cell culture induced a better differentiation of osteoblasts. Thosepositive results have then been confirmed in vivo on ovariectomized mice,used to simulate a postmenopausal osteoporosis, which leads to a lower bonemineral density (BMD).
Animals were divided into three groups: a control group (nonovariectomized), a group of ovariectomized mice, both fed with a normal dietand a group of ovariectomized mice that received a diet containingPeptan(TM). After 12 weeks, the BMD of the group fed with Peptan(TM) is notsignificantly different from the BMD of control group. On the contrary theBMD of ovariectomized mice not fed with Peptan(TM) is lower.
Confirmation of Peptan(TM) benefits on bone health has been obtained bythe measures of Carboxy Terminal Telopeptide (CTX), a usual marker of boneresorption. CTX is significantly lower in mice fed with Peptan(TM) indicatingthat bone resorption is reduced.
Researchers conclude that Peptan(TM) may restore bone density insimulated post-menopausal osteoporosis by stimulating osteoblast growth anddifferentiation. This demonstrates the interest of Peptan(TM) as a bioactiveingredient to help preventing bone loss during aging.
*Hydrolyzed collagen improves bone metabolism and biomechanicalparameters in ovariectomized mice: an in vitro and in vivo study.Guillerminet et al. Bone 2009.
Rousselot, http://www.rousselot.com
Part of VION N.V. (N.L.), Rousselot(R) is the worldwide leader ingelatine and hydrolyzed collagen. VION N.V. is an internationally operatingfood group that produces high-quality foods and ingredients for humans andanimals (Turnover: EUR 9.6 billion - 31,000 employees worldwide)
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