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Pressure Cycling Technology (PCT) Highlighted in Five Podium Presentations at the Fifth International Conference on High Pressure; PBI Introduces the Patent-pending 'PCT Shredder' at the Meeting

Wednesday, September 24, 2008 General News J E 4
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SOUTH EASTON, Mass., Sept. 23 PressureBioSciences, Inc. (Nasdaq: PBIO) ("PBI" or the "Company") today announced thatthe Company's pressure cycling technology ("PCT") was highlighted in fiveseparate podium presentations at the Fifth International Conference on HighPressure Bioscience and Biotechnology ("HPBB"), held from September 15-19,2008 in San Diego, CA. The HPBB Conference was attended by nearly 100 highpressure research scientists from government, academic, and industrylaboratories from around the world. PBI was one of several sponsors tosupport the meeting.

Dr. Nathan Lawrence, Vice President of Marketing for PBI said: "We arevery pleased to have been prominently featured at a conference of world classscientists working in applications of high pressure. In addition to twopresentations by PBI scientists, three other talks were presented by users ofthe PCT Sample Preparation System. Dr. Bradford Powell of the U.S. ArmyMedical Research Institute of Infectious Diseases (USAMRIID) was selected togive an opening scientific presentation entitled "Use of Pressure CyclingTechnology (PCT) in Sample Decontamination and Biomolecule Extraction forAnalysis of the Anthrax Spore Proteome." In addition, Dr. Daniel Lopez-Ferrerof Pacific Northwest National Laboratories (PNNL) discussed the significantadvantages offered by PCT in the study of proteins in his presentationentitled "Application of Pressure for Ultra Fast Protein Digestion inProteomics." Finally, Dr. Yiping Cao of the Southern California WaterResearch Project (SCWRP) gave a presentation entitled "Comparison of PressureCycling and Bead Beating Technologies for DNA Extraction from PolycarbonateMembranes for Water Quality Analysis." These presentations illustrate thebreadth of applications afforded by PCT. We believe that exposure at meetingssuch as HPBB will help PBI reach its goal of worldwide market leadership inhigh pressure bioscience and biotechnology."

PBI also announced that it introduced its patent-pending "PCT Shredder"during the HPBB Conference, the third new PCT-dependent product that theCompany has released over the past four months. The PCT Shredder was designedto help research scientists safely, rapidly, and conveniently disrupt verytough samples -- such as ticks, muscle, and seeds -- that requirehomogenization prior to PCT or other sample preparation methods.

Mr. Richard T. Schumacher, Founder, President, and CEO of PBI commented:"Extremely tough samples often require a pre-processing step as part of thesample preparation process. The PCT Shredder was designed to rapidly andsafely process a wide range of such samples. It uses the same PULSE Tube asthe PCT Sample Preparation System (PCT SPS). This allows scientists tohomogenize tough samples in the PCT Shredder followed directly by extractionwith the PCT SPS, but without the need to transfer the sample into a secondprocessing container between steps. This is unique to the sample preparationmarket. We believe this reduction in sample handling should result in adecrease in cost for the user and a potential reduction in sample loss andlaboratory errors. We further believe that the advantages of the PCT Shredderwill help us significantly in our goal to achieve greater market acceptanceand penetration, and leadership in the worldwide sample preparation field."

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded company focused onthe development of a novel, enabling technology called Pressure CyclingTechnology (PCT). PCT uses cycles of hydrostatic pressure between ambient andultra-high levels (up to 35,000 psi and greater) to control bio-molecularinteractions. PBI currently holds 13 US and 6 foreign patents coveringmultiple applications of PCT in the life sciences field, including such areasas genomic and proteomic sample preparation, pathogen inactivation, thecontrol of
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