PCI Biotech and RXi Pharmaceuticals Extend Research Collaboration to the Field of Immuno-oncology

Monday, May 22, 2017 Cancer News
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OSLO, Norway and MARLBOROUGH, Mass., May 22, 2017 /PRNewswire/ -- PCI Biotech (OSE: PCIB),

a cancer focused biopharmaceutical company, and RXi Pharmaceuticals (NASDAQ: RXII) a biotechnology company focused on developing novel RNAi therapeutics for significant un-met needs, today announced that they are extending their preclinical research
collaboration initiated April 7, 2015.

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This extension is supported by a new preclinical research collaboration agreement that reflect RXi's recently completed acquisition of MirImmune and PCI Biotech's focus in oncology. In brief, the preclinical research collaboration will evaluate technology compatibility and synergy based on in vivo studies. The companies will evaluate results achieved from this research collaboration and then explore the potential for a further partnership.

Dr. Per Walday, CEO of PCI Biotech, said: "I'm very pleased to announce the extension of the existing research agreement. Our collaboration with RXi has been most fruitful and demonstrated a clear positive technological synergy that could realise significant value when applied to the emerging field of immuno-oncology. We look forward to exploring synergies between fimaNAc and RXi's innovative RNAi based compounds in the extended collaboration focusing on immuno-oncology opportunities."

"Our collaboration with PCI Biotech over the last two years has been mutually very beneficial for our Companies," said Dr. Geert Cauwenbergh, President and CEO of RXi Pharmaceuticals. He added that, "We will learn how the PCI technology can even further enhance the time and the concentration our sd-rxRNA compounds can reside and be active in the immune cells. In the immuno-oncology space, where everybody talks about potency and safety of combinations, this continued and more focused collaboration could advance this therapeutic area significantly."

About PCI Biotech         

PCI Biotech is a biopharmaceutical company focusing on development and commercialisation of novel therapies for the treatment of cancer through its innovative photochemical internalisation (PCI) technology platform.  PCI is applied to three distinct anticancer paradigms: fimaChem (enhancement of chemotherapeutics for localised treatment of cancer), fimaVacc (T-cell induction technology for therapeutic vaccination), and fimaNAc (nucleic acid therapeutics delivery).

Photochemical internalisation induces triggered endosomal release that is used to unlock the true potential of a wide array of therapeutic modalities. The company's lead fimaChem programme consists of a clinical Phase I/II clinical study in bile duct cancer, an orphan indication with a high unmet need and without approved products.  fimaVacc applies a unique mode of action to enhance the essential cytotoxic effect of therapeutic cancer vaccines, which works in synergy with several other state-of-the-art vaccination technologies.  fimaNAc utilises the endosomal release to provide intracellular delivery of nucleic acids, such as mRNA and RNAi therapeutics, thereby addressing one of the major bottlenecks facing this emerging and promising field.

About RXi Pharmaceuticals Corporation

RXi Pharmaceuticals Corporation (NASDAQ: RXII) is a clinical-stage company developing innovative therapeutics that address significant unmet medical needs. Building on the pioneering discovery of RNAi, scientists at RXi have harnessed the naturally occurring RNAi process which has the ability to "silence" or down-regulate the expression of a specific gene that may be overexpressed in a disease condition. RXi developed a robust RNAi therapeutic platform including self-delivering RNA (sd-rxRNA®) compounds, that have the ability to selectively block the expression of any target in the genome, thus providing applicability to many therapeutic areas. Our current programs include dermatology, ophthalmology and cell-based cancer immunotherapy. RXi's extensive patent portfolio provides for multiple product and business development opportunities across a broad spectrum of therapeutic areas and we actively pursue research collaborations, partnering and out-licensing opportunities with academia and pharmaceutical companies. Additional information may be found on the Company's website, www.rxipharma.com.

Contact

PCI Biotech Holding ASA   Per Walday, CEO   +47 917 93 429   [email protected]

RXi Pharmaceuticals Corporation   Tamara McGrillen   508-929-3646   [email protected]  

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/pci-biotech-and-rxi-pharmaceuticals-extend-research-collaboration-to-the-field-of-immuno-oncology-300461227.html

SOURCE RXi Pharmaceuticals Corporation



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