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Osteotech's Plexur(R) Technology to Be Used in Craniofacial Reconstruction Program Funded by the Armed Forces Institute of Regenerative Medicine

Saturday, May 3, 2008 General News
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EATONTOWN, N.J., May 2 Osteotech, Inc.(Nasdaq: OSTE), a leader in the emerging field of biologic solutions forregenerative healing, announced today that its Plexur(R) Technology will beused in a Craniofacial Reconstruction Program led by Dr. Jeffrey Hollinger ofCarnegie Mellon University. This program, which was prepared under theauspices of the New Jersey Center for Biomaterials and Dr. Joachim Kohn ofRutgers University, is part of a multi-institutional effort funded by a $42.5million grant from the Armed Forces Institute of Regenerative Medicine(AFIRM). AFIRM was recently created by the United States Department of Defenseto provide funding for the development of regenerative technologies that canbe used to treat the most critically injured service members, as well ascivilian patients.
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The reconstruction program looks to create a new Plexur(R) Biocompositemade of allograft bone fibers or particles and utilizes a novel biodegradablepolyurethane to facilitate healing and improve outcomes. This new Plexur(R)Biocomposite will be developed through the collaborative efforts of Dr.Hollinger, Dr. Scott Guelcher at Vanderbilt University, and Osteotech'sscientific team. Osteotech has had a long-standing working relationship withDr. Hollinger and Dr. Guelcher.
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Sam Owusu-Akyaw, Osteotech's President and Chief Executive Officer,stated, "We are very pleased and proud that our Plexur(R) Technology will beused in this research effort at Vanderbilt University and Carnegie MellonUniversity. The need is great for regenerative solutions to treat serioustraumatic injuries to the skull due to wartime injuries. Our Plexur(R)Technology has the potential to offer new solutions in reconstruction of thecraniofacial region and elsewhere in the body to treat damage from these verydifficult injuries."

Osteotech previously obtained a license from Carnegie Mellon Universityfor the biodegradable polyurethane that is to be used in this program. Thisbiodegradable polyurethane, in combination with Osteotech's Plexur(R)Technology, has been licensed to Vanderbilt University for research purposes.The collaborative research efforts are directed in part, towards developing abiocomposite that has unique characteristics, including high compressive,torsional or bending strength. Osteotech has the rights to any productdeveloped within its current Plexur(R) intellectual property estate and anon-exclusive right to any technology improvements.

The Plexur(R) Technology uses bone tissue for procedure-specific surgicalapplications in combination with a wide variety of polymers. On a world-widebasis, Osteotech controls over 33 patents and over 65 pending patentapplications covering this technology for human and xenograft bone tissue. Formore information about the Plexur(R) Technology or Osteotech's Plexur P(TM) orPlexur M(TM) Biocomposites, please go to the Osteotech website athttp://www.osteotech.com.

The New Jersey Center for Biomaterials is an academic research center atRutgers, The State University of New Jersey. The center links researchuniversities nationwide with industry and government to develop advancedmaterials for tissue repair and replacement, and drug delivery systems.Technology invented at the center is currently being licensed by threecompanies for the development of cardiovascular, ophthalmic and surgicalimplants. For further information regarding the New Jersey Center forBiomaterials, please visit http://www.njbiomaterials.com.

Osteotech, Inc., headquartered in Eatontown, New Jersey, is a globalleader in providing OsteoBiologic solutions for regenerative medicine tosupport surgeons and their patients in the repair of the musculoskeletalsystem through the development of innovative therapy-driven products thatalleviate pain, promote biologic healing and restore function. For furtherinformation regarding Osteotech or this press release, please go toOst
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