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NxStage Expands System One(TM) Network Coverage for ESRD Patients

Saturday, June 28, 2008 General News
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LAWRENCE, Mass., June 27 NxStage Medical, Inc.(Nasdaq: NXTM), a leading manufacturer of innovative dialysis products, todayannounced that based on recent data compiled from its patient database matchedwith CMS public data, approximately 92 percent of End-Stage Renal Disease(ESRD) patients within the continental United States are now located within a60 mile radius of a dialysis center which offers System One(TM) therapy.
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"We are extremely pleased to have increased ESRD patient and physicianaccess to System One via our comprehensive and growing network of dialysiscenters," said Jeff Burbank, Chief Executive Officer. "We are committed tofurther develop and invigorate these programs to deepen our penetration andextend the quality of life benefits of home dialysis to more patients."
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The Company also announced the appointment of Jeff Smith to the newlycreated position of Vice President and General Manager, Home Market. Mr.Smith joins NxStage from Insulet Corporation, where as Vice President ofMarketing and Business Development he played a key role in commercializing anext generation wearable insulin pump for diabetes patients.

"Jeff is a strong addition to our team and rounds out NxStage's leadershipcapabilities across our three growing markets: home, critical care andin-center," said Burbank.

"Jeff will spearhead efforts intended to create momentum and grow our homemarket," said Joseph Turk, Senior Vice President, Commercial Operations. "Hewill be exclusively focused on building awareness and delivering tools thatdemonstrate the superior clinical and economic benefits associated with ourhome daily dialysis products to patients, physicians, providers and payors.Jeff brings exceptional marketing and commercial knowledge to this role, andhas considerable experience in developing markets for medical devices," saidTurk.

Mr. Smith joins two other seasoned executives, John Westman and MarkFlorence, who serve as Vice Presidents and General Managers of NxStage'sCritical Care and In-Center/Medisystems Markets, respectively. Mr. Florencejoined NxStage in January 2008, and Mr. Westman has been leading the criticalcare team since September 2005.

Mr. Smith served four years with Insulet Corporation after serving for 22years with Abbott Labs in various roles, most recently as Divisional VicePresident of Medisense, Abbott's consumer diabetes care franchise. Prior, Mr.Smith was General Manager of Abbott Diagnostics (Canada) and was Director ofRoss Products Sales and Marketing.

About NxStage Medical

NxStage Medical, Inc. (Nasdaq: NXTM) is a medical device company,headquartered in Lawrence, Massachusetts, USA, that develops, manufactures andmarkets innovative products for the treatment of end-stage renal disease, orESRD, and acute kidney failure. For more information on NxStage and itsproducts, please visit the company's website at http://www.nxstage.com.

Forward-Looking Statements

This release contains "forward-looking statements" within the meaning ofthe Private Securities Litigation Reform Act of 1995. All statements containedin this release that are not clearly historical in nature are forward-looking,and the words "anticipate," "believe," "expect," "estimate," "plan" andsimilar expressions are generally intended to identify forward-lookingstatements. Examples of these forward-looking statements include statements asto the contributions Messrs. Smith, Florence and Westman will make to theCompany's performance and operating results, expectations as to the growth inour three markets, and expectations as to the development of the home dialysismarket, in particular. All forward-looking statements involve risks,uncertainties and contingencies, many of which are beyond NxStage's control,which may cause actual results, performance or achievements to differmaterially from anticipated results, performance or a
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