New Study Shows Honokiol Supports Kidney Cellular Health

Tuesday, September 13, 2016 Research News J E 4
Honokiol Suppresses RhoA/ROCK/MLC Signaling Involved in Cell Proliferation

SANTA ROSA, Calif., Sept. 13, 2016 /PRNewswire/ --  Clinical Synergy® Professional Formulas announces a new study published in the International Journal of Oncology by the Cancer Research Laboratory, Indiana University Health, suggesting that honokiol supports kidney health and function by suppressing cell proliferation and migration. The mechanism is associated with the increase in actin stress fibers and phosphorylated myosin light chain (MLC). These findings demonstrated that honokiol suppresses RhoA/ROCK/MLC signaling, a pathway that regulates cytoskeleton actin fiber contractions that are involved in cell division.

Pure Honokiol, from Clinical Synergy Professional Formulas, is extracted from the bark of Magnolia officinalis and is the highest purity available on the market. There are thousands of published articles on honokiol and these studies show that this unique botanical extract has multiple mechanisms of action and the ability to cross the blood-brain barrier. Honokiol supports several indications from healthy mood and relaxation to cellular health.

In this new study, honokiol demonstrated suppression of proliferation of human renal cells. In addition, honokiol inhibited migration of highly intrusive renal cells and stimulated RhoA activity, with phosphorylated MLC and excessive formation of actin stress fibers identified in the cells treated with honokiol. Together, these important findings suggest that honokiol suppresses the migration of invasive renal cells through activation of RhoA/ROCK/MLC signaling, warranting further attention and clinical studies to support kidney cellular health.

"This paper is a huge advancement in the research of honokiol," states Isaac Eliaz, MD, coauthor on the study. "This study helps shine light on the true potential of this biologically active small molecule. We are excited to see people interested in this multi-targeted botanical extract and the multitude of promising studies, from cellular to cognitive support."

A dedicated health practitioner line, Clinical Synergy® Professional Formulas is a doctor formulated, research driven brand of dietary supplements for use under guidance of a qualified healthcare practitioner. To learn more, visit

Source: Cheng S, Castillo V, Welty M, et al. Int. J. Oncol. 2016 Aug;49(4):1525-30.

FOR MORE INFORMATION CONTACT:Ruby JordanMedia Contactinfo@clinicalsynergyformulas.com877-877-2362


To view the original version on PR Newswire, visit:

SOURCE Clinical Synergy Professional Formulas



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