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New Data From Lilly Oncology Pipeline To Be Presented at ASCO 2010

Wednesday, May 12, 2010 General News J E 4
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INDIANAPOLIS, May 12 Data from several Lilly Oncology compounds in development - a total of 13 studies - will be presented during the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) held in Chicago, Ill. from June 4 - 8, 2010. Lilly Oncology's pipeline is one of the largest in the industry, with more than 20 molecules in development.

The pipeline data include two Phase II studies evaluating the use of tasisulam (a novel anti-cancer agent) and ramucirumab (an IgG1 monoclonal antibody) as second-line therapies in patients with unresectable or metastatic melanoma (ASCO Abstracts #8541 and #8519). Pipeline data will also be presented on Lilly's cixutumumab (also an IgG1 monoclonal antibody).

"Through our ongoing research efforts around the world, we continue to invest significant resources to fuel innovation," said Richard Gaynor, M.D., vice president, product development and medical affairs at Lilly Oncology. "In less than two years, we have moved three additional oncology molecules into five major Phase III trials in therapeutic areas with significant unmet medical needs."

Nearly all the molecules in Lilly's pipeline are being evaluated for certain biomarkers that can help researchers identify which patients are most likely to respond to these medicines, and as importantly, which are not.

"At Lilly, we know that with cancer time is everything," said Gaynor. "As such, we've built an innovative research strategy - in our own labs and in collaboration with several partners - to look for ways to tailor medicine in a way that can improve outcomes for individual patients facing cancer."

Studies of note for tasisulam include:

Studies of note for ramucirumab include:

Studies of note for cixutumumab include:

P-LLY

This press release contains forward-looking statements about the potential of tasisulam, ramucirumab and cixutumumab and reflects Lilly's current beliefs. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of development and commercialization. There is no guarantee that the product will continue to be commercially successful. For further discussion of these and other risks and uncertainties, see Lilly's filings with the United States Securities and Exchange Commission. Lilly undertakes no duty to update forward-looking statements.

(Logo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO )

-- Abstract #8541: General Poster Session: Sunday, June 6, 2010, 8:00 a.m. - 12:00 p.m. -- A phase II study of tasisulam sodium (LY573636) as second-line treatment for patients with unresectable or metastatic melanoma -- Author/ Speaker: John Munn Kirkwood -- Location: S Hall A2; Poster Board: 49A

SOURCE Eli Lilly and Company
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