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NeurogesX to Present at CIBC World Markets 18th Annual Healthcare Conference and Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference

Wednesday, October 31, 2007 General News J E 4
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SAN MATEO, Calif., Oct. 31 NeurogesX, Inc.(Nasdaq: NGSX), a biopharmaceutical company focused on developing novel painmanagement therapies, announced today that it is scheduled to present onMonday, November 5, 2007 at the CIBC World Markets 18th Annual HealthcareConference and on Tuesday, November 6, 2007 at the Acumen BioFin Rodman &Renshaw 9th Annual Healthcare Conference. Anthony DiTonno, President andChief Executive Officer, will be presenting and Stephen Ghiglieri, ChiefFinancial Officer, will be available to respond to questions during the breakout sessions.

An audio Web cast of the Company's presentations will be available bygoing to the investor relations section of NeurogesX' Web site atwww.neurogesx.com. A replay of the presentation will be available for 15days.

About NeurogesX, Inc.

NeurogesX (Nasdaq: NGSX) is a biopharmaceutical company focused ondeveloping novel pain management therapies. Its initial focus is on chronicperipheral neuropathic pain, including postherpetic neuralgia (PHN), painfulHIV-distal sensory polyneuropathy (HIV-DSP) and painful diabetic neuropathy.NeurogesX' late stage product portfolio is led by its product candidateNGX-4010, a dermal patch designed to manage pain associated with peripheralneuropathic pain conditions, that the company believes offers significantadvantages over other pain therapies. Three Phase 3 clinical trials withNGX-4010 have been completed and have met their primary endpoints, two in PHNand one in painful HIV-DSP.

Safe Harbor Statement

This press release contains forward-looking statements for purposes of thePrivate Securities Litigation Reform Act of 1995 (the "Act"). NeurogesXdisclaims any intent or obligation to update these forward-looking statements,and claims the protection of the Safe Harbor for forward-looking statementscontained in the Act. Examples of such statements include, but are notlimited to, the timing of presentations by NeurogesX and the expected benefitsof NeurogesX' potential products, including its lead product candidateNGX-4010. Such statements are based on management's current expectations, butactual results may differ materially due to various risks and uncertainties,including, but not limited to, past results of clinical trials may not beindicative of future clinical trials results; NeurogesX' product candidate mayhave unexpected adverse side effects or inadequate therapeutic efficacy;positive results in clinical trials may not be sufficient to obtain FDA orEuropean regulatory approval; physician or patient reluctance to use NGX-4010,if approved, or the inability of physicians to obtain sufficient reimbursementfor such procedures; potential alternative therapies; maintaining adequatepatent or trade secret protection without violating the intellectual propertyrights of others; and other difficulties or delays in clinical development,obtaining regulatory approval, market acceptance and commercialization ofNGX-4010 and the advantages of NGX-4010 over other pain therapies. Forfurther information regarding these and other risks related to NeurogesX'business, investors should consult NeurogesX' filings with the Securities andExchange Commission.Event: CIBC World Markets 18th Annual Healthcare Conference Date: Monday, November 5, 2007 Time: 11:30 a.m. ET Place: The Waldorf-Astoria Hotel, New York Event: Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference Date: Tuesday, November 6, 2007 Time: 10:55 a.m. ET Place: New York Palace Hotel, New York

SOURCE NeurogesX, Inc.
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