NEWS: Benefits of Lifestyle Changes or Metformin Treatment Persist After 10 years in People at High Risk for Type 2 Diabetes
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About 24 million people in the United States have diabetes. It is the main cause of kidney failure, limb amputations, and new onset blindness in adults and a major cause of heart disease and stroke. Type 2 diabetes, which accounts for up to 95 percent of all diabetes cases, becomes more common with increasing age. The prevalence of diagnosed diabetes has more than doubled in the last 30 years, due in large part to the upsurge in obesity.
After following participants in the Diabetes Prevention Program Outcomes Study (DPPOS) for 10 years, researchers conclude that intensive lifestyle changes aimed at modest weight loss reduced the rate of developing type 2 diabetes by 34 percent compared with placebo in people at high risk for the disease. Participants randomly assigned to make lifestyle changes also had more favorable cardiovascular risk factors, including lower blood pressure and triglyceride levels, despite taking fewer drugs to control their heart disease risk. Treatment with the oral diabetes drug metformin reduced the rate of developing diabetes by 18 percent after 10 years compared with placebo. Results of the study appear online in The Lancet on October 29, 2009.
Other studies have shown that diet and exercise delay type 2 diabetes in at-risk people. However, this study, a continuation of the Diabetes Prevention Program, is the first major trial to show that lifestyle changes can effectively delay diabetes in a diverse population of overweight American adults at high risk of diabetes. The study was conducted at 27 medical centers nationwide (www.bsc.gwu.edu/dpp/clinics.htmlvdoc).
[Credentialed reporters may access the embargoed NIH news release at www.eurekalert.org.]
B-ROLL INCLUDES: Exteriors and Interiors of NIH** Dr. Rodgers and Dr. Nathan at work**Study participants (e.g., preparing food, eating, exercising, checking weight, meeting with staff at a study center, and handling medication)**People walking
VIDEO PROVIDED BY: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, part of the U.S. Dept. of Health and Human Services
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SOURCE National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, part of the U.S. Dept. of Health and Human Services