Medco Delivers Second-Quarter 2010 GAAP Diluted EPS Growth of 20.3 Percent to a Record $0.77; Diluted EPS, Excluding Amortization of Intangible Assets, Increased 20.3 Percent to a Record $0.83

Medco Health Solutions, Inc.Guidance Information(Unaudited)

Full Year Ended

Estimated

December 26, 2009

Full Year Ended December 25, 2010

Actual

Low End

High End

$                        2.61

$                3.10

$                3.15

0.22

0.24

0.24

$                        2.83

$                3.34

$                3.39

19%

21%

18%

20%