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Major State Grant Accelerates Research and Development of Novel Cancer Therapy

Saturday, September 6, 2008 General News J E 4
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BOCA RATON, Fla., Sept. 5 The Florida Technology, Research and Scholarship Board recently awarded Florida Atlantic University researcher Dr. Herbert Weissbach, distinguished professor and director of the Center for Molecular Biology and Biotechnology in the Charles E. Schmidt College of Science, and CHS Resources LLC (CHS), $184,294 as part of the State University Research Commercialization Assistance Grant program (SURECAG). SURECAG was established by the Florida Legislature in 2007 to promote the commercialization of university research products to enhance the state's economy and its public universities. With these funds, universities are able to promote their commercialization endeavors by securing patents, establishing startup companies, developing licensing agreements and attracting private investments.



FAU, together with CHS (which licensed this technology from FAU), submitted a proposal for Weissbach's discovery of a novel combination of agents that work to preferentially target and kill cancer cells. In addition, CHS was instrumental in providing FAU with a matching grant -- a stipulation of the SURECAG program -- for a total of $368,588 for research and development. CHS is currently developing this therapy for treatment of actinic keratosis (AK), a precancerous skin condition, and "proof-of-concept" studies are ongoing. CHS is simultaneously developing an over-the-counter skin protective agent with unique antioxidant properties.



"SURECAG is designed to create a more vital link between venture capitalists, industry and Florida's state universities," said Dr. Gary Perry, dean of the Charles E. Schmidt College of Science. "This grant is essential to support product development activities necessary to help CHS obtain approval from the FDA to perform clinical trials that will lead to drug approval."



Weissbach and his team initially identified a lead compound that in combination with an oxidizing agent or agent that generates reactive oxygen species selectively targets and kills cancer cells, but not normal cells. Based on these findings, they formulated a topical skin preparation for CHS which is currently being tested for treatment of AK. Ongoing research of this therapy is also underway in Weissbach's laboratory to determine the mechanisms of action of the drug combination, and to design and synthesize more active derivatives as potential anti-cancer agents.



"Innovation is one of the single-most important factors in determining America's future success and our ability to lead the way in discoveries that save lives and improve the quality of life," said Stephen Chakoff, president of CHS. "The SURECAG funds will enable CHS to continue our efforts to develop the topical skin drug product and hopefully position our company for a private placement and equity fund investment to bring this drug product utilizing the FAU-licensed intellectual property through FDA trials and into the marketplace."



FAU will benefit through the licensing fees as CHS achieves its milestones and through royalties from the sale of products based on FAU's intellectual property. FAU will maintain a stake in CHS and will be able to build a world-wide intellectual property portfolio to enhance the programs surrounding this discovery.



"This is an important step forward," said Weissbach. "The SURECAG program will enable both FAU and CHS to move the project forward with the hope of obtaining a new therapy to treat skin and other cancers. Furthermore, CHS is adding to the growing life science sector in Florida, a state that has a high incidence of skin cancer."



Skin cancer is the most prevalent form of cancer in the world. The two most common types of non-melanoma skin cancers are basal cell carcinoma and squamous cell carcinoma (SCC). One in five Americans will develop some form of skin cancer at some point in th
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