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The most recent study shows mega-dose resveratrol alone fails to prolongthe life of laboratory mice. In fact, mega-doses shortened the life ofanimals compared to a standard calorie diet with no resveratrol. [CellMetabolism. 2008 Aug; 8:157-68]
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"While resveratrol (rez-vair-ah-trol), an antioxidant moleculeconcentrated in red wine (about 1 milligram per glass), is touted for itshealth properties, partially explaining the French Paradox (why French winedrinkers have cardiac mortality rates 30% lower than North Americans despitetheir high-calorie, high-fat diets), it is not the sole molecule responsiblefor longevity," says Bill Sardi, spokesperson for Longevinex(R), a leadingbrand of resveratrol dietary supplement.
"The total array of red wine molecules found in the best red wine, about60 milligrams per 5-ounce glass, or 180-300 milligrams in 3 to 5 glasses, isthe suggested healthy dosage range," says Sardi.
Consistently, studies show modest doses of red wine lower mortality ratesover abstention or over-consumption. [American Journal Epidemiology 1986 Sep;124(3):481-9] Red wine pills offer the advantage of no alcohol, no caloriesor sulfite preservatives.
Cause of shortened lifespan
The negative effect upon lifespan with mega-dose resveratrol may emanatefrom over-inhibition of tumor necrosis factor (TNF), an inflammatory factor.Excessive TNF leads to inflammation, while too little impairs the immunesystem, says Sardi.
"We know that over-inhibition of TNF in humans increases the risk forlymphoma (cancer that originates in lymphocytes, a type of white blood cell),"says Sardi. [Therapeutics Clinical Risk Management 2007 Jun; 3(2):245-58]"When laboratory mice were given mega-dose resveratrol they did not live aslong and largely succumbed to lymphoma. Resveratrol is a known TNFinhibitor," adds Sardi. [Biochemical and Biophysical Research Communications2008 May 2; 369(2):471-7]
Confusing dosage advice
While longevity seekers have been hearing a lot about resveratrol in thepast four years, since an Ivy League university discovered it activated alongevity gene known as Sirtuin 1, advice concerning dosage has been confusingat times.
A 2006 mouse study suggested consumers would have to drink about 750 to1500 bottles of red wine a day to live longer (24 milligrams per kilogram ofbody weight), but the longevity effect was only demonstrated among miceengorged with a fat-laden diet (60% fat calories vs. 35% for the typical humandiet), which isn't a real-world example.
When the data on mice fed a standard calorie diet were analyzed andpublished in 2008 [Cell Metabolism. 2008 Aug; 8(2):157-68], ultra-high doseresveratrol (360 mg and 1565 mg, human equivalent dosage) actually stunted thelifespan of mice. So the public has been misled concerning dosage since 2006[Nature 2006 Nov 16; 444:337-42], and may have never heard about the 2008report, says Sardi.
Lower dose resveratrol accompanied by an array of other small moleculesmay be superior to resveratrol alone. According to a mouse study conducted byLongevinex(R), published in the September 2008 issue of ExperimentalGerontology [2008 Sept; 43(9):859-66], far more longevity genes were activatedin heart tissue by Longevinex (9-fold more) than plain resveratrol, at a dosethat was 17-320 times lower than doses used in prior studies.
Synergism found
"A synergistic effect has been demonstrated with the array of antioxidantmolecules provided in Longevinex(R), compared to resveratrol alone," saysSardi. Other studies also corroborate that resveratrol works better whenaccompanied by other molecules, at lower doses. [Journal Medicinal Food 2008Dec; 11:773-83; Translational Oncology 2008 March; 1:19-27; Life Science 2008May 7; 82: 1032-9]
Sardi says longevity seekers often demand human lifespan studies, notrealizing such a study would be impractical, taking 100 years to complete.Mouse longevity studies take about 3-4 years and cost more than a milliondollars, so more economical gene array studies are performed and comparedagainst a calorie restricted diet, which is a known intervention that prolongslife in all life forms. Longevinex(R) also sponsored an unpublished studyshowing it activated far more genes in brain tissue than plain resveratrol.
Longevinex(R) is a patent-applied-for matrix providing 250 milligrams ofgene-controlling molecules (resveratrol, quercetin, rice bran IP6, ferulicacid, vitamin D), and is currently the only resveratrol-based dietarysupplement to have been successfully studied in humans. Researchers atAppalachian State University found Longevinex(R) had superior antioxidant andanti-inflammatory action among endurance athletes compared to green teamolecules or quercetin alone.
Longevinex(R) is microencapsulated for stability and long-term shelf life,and is micronized to enhance absorption. Longevinex(R) contains no alcohol.Longevity seekers are invited to visit the website at www.longevinex.com
SOURCE Longevinex
