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ISTO Technologies, Inc. Appoints Blake Miles as Vice President of Sales

Tuesday, November 13, 2007 General News J E 4
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ST. LOUIS, Nov. 13 ISTO Technologies, Inc. a privatelyheld orthobiologics company, today announced the appointment of Blake Miles asVice President of Sales.

ISTO President and CEO Mitchell Seyedin said, "We are pleased to attract aproven talent from the medical device industry, with an impressive knowledgeof orthobiologic products." Prior to joining ISTO, Blake was a Regional SalesManager with a distributorship for Depuy Spine, Inc. a global designer,manufacturer, and supplier of spinal devices and a subsidiary ofJohnson & Johnson. Mr. Miles has 14 years of sales and marketing experience.His tenure in medical sales included successful senior level sales positionswith Medtronic Sofamor Danek, Ansell Healthcare, Kos Pharmaceutical, andPhysician Sales & Service. "Throughout his career, Blake has shown leadershipand an entrepreneurial spirit in managing successful sales teams in theorthopedic field," said Seyedin. Mr. Miles will organize and drive a salesdistributor network to launch ISTO's first commercial product, InQu, a bonegraft extender and substitute.

InQu represents a new class of synthetic biomaterial scaffold designed tooptimize structural and biological properties to support bone cell growth.InQu is a biopolymer composite of hyaluronic acid which is entangled withinthe three-dimensional backbone created by synthetic polyester. Hyaluronicacid, a ubiquitous component of natural tissue, is known to play a predominantrole in tissue morphogenesis, cell migration, adhesion, and celldifferentiation.

In addition to its biomaterial platform technology, ISTO is alsodeveloping cartilage regeneration products centered on its patented cell-basedtechnology. Cartilage regeneration is often called the "holy grail" of theorthopedic industry because of its potential to restore function to damagedjoints that otherwise have limited healing potential. Cartilage serves as a"shock absorber" protecting all joints, including spinal discs, from the wearand tear experienced during motion. ISTO's first cartilage product iscurrently in clinical trials.

About ISTO

ISTO Technologies, Inc. is an orthobiologics company focused on developingdifferentiated products for sports medicine, spinal therapy, and trauma.ISTO's products are intended for the repair and regeneration of damaged orinjured cartilage and bone. For additional information on ISTO, please visitour website at http://www.istotech.com or contact the company at314-995-6049.

SOURCE ISTO Technologies, Inc.
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