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Contextual data analysis enhances IPA's powerful search and analysiscapabilities by enabling researchers to refine their experimental analyses anddevelop scientific hypothesis based on findings that have been demonstrated tooccur in a particular species, cell types, tissues, bio-fluids, biologicalprocesses, cellular functions, chemicals, and disease of interest. Forexample, a CNS researcher can run an analysis and identify molecularinteractions and gene to phenotype associations that have specifically beendemonstrated in CNS tissues or cell lines -- effectively narrowing thehypothesis space to those most closely aligned with their experimental model.
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Patrick De Boever, Ph.D., Flemish Institute for Technological Research(VITO), noted, "The new tools in IPA 7 are great for constructing species-specific biological interaction networks from our toxicogenomics data. Thisapproach enabled us to reveal molecules that hold potential as bloodbiomarkers for neurotoxic effects induced by environmental pollutants."
Additional features have been added in IPA 7 to support researchers'workflows including:
About Ingenuity Pathways Analysis
Ingenuity Pathways Analysis is an all-in-one software application thatenables researchers to model, analyze, and understand the complex biologicaland chemical systems at the core of life science research. IPA's searchcapabilities provide users with access to the highest quality detail-richknowledge available on genes, drugs, chemicals, protein families, cellular anddisease processes, and signaling and metabolic pathways. IPA supports analysisof data from all experimental platforms, and is used at all stages of the drugdiscovery and development process, including target identification andvalidation, biomarker discovery, molecular toxicology, metabolomics, andpharmacogenomics. IPA has been broadly adopted and cited in hundreds ofpeer-reviewed journals(http://www.ingenuity.com/library/pdf/bibliography.pdf).
About Ingenuity Systems(R)
Ingenuity Systems is a leading provider of information solutions andcustom services for life science researchers, computational biologists andbioinformaticists, and life science industry suppliers. Our long-term focus oninnovation in semantic search has allowed us to create groundbreakingtechnologies that have one common goal -- to generate maximum value from alltypes of biological and chemical knowledge. Ingenuity offerings leverage theIngenuity Knowledge Base, which contains uniquely structured literaturefindings that allow scientists to ask complex biological questions and gainrapid insight into their experimental data or systems of interest. Today,Ingenuity's solutions are used by thousands of researchers at hundreds ofleading pharmaceutical, biotechnology, academic, and government researchinstitutions worldwide. http://www.ingenuity.com-- microRNA target information -- New Reporting Tools -- New Signaling Pathways -- Additional Chemical Content
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