Highest Replikin Concentrations and Cyclical Behavior Related to Human Mortality Are Found in Malaria Trypanosomes

Monday, May 19, 2008 General News
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BOSTON, May 19 Replikins Ltd. has found that very highconcentrations of its replikin genetic sequences are found in the trypanosomesthat are the infectious agents in malaria. The levels found by the company arein fact the highest replikin concentrations observed to date in any infectiousdisease agent. The company has also found that these concentrations cycle overseveral years.

Replikins appear to be possible agents or promoters of infectivity, hostmorbidity and mortality. Timely repeated analyses of cyclic changes in anorganism's replikin structure may be useful to bring current the targets forthe chemical synthesis of ReplikinBestFit(TM) vaccines. These strain-specificvaccines, manufactured in 7 days, were recently shown to protect 91% of shrimpagainst the lethal Taura Syndrome Virus.

To obtain the current malaria results, publicly-available protein sequencedata on Pl. Falciparum, the most common strain in malaria, were gathered fromthe Pubmed online listing, and examined against World Health Organization dataon human malaria deaths for each year between 1986 and 2007. The quantitativereplikin concentration (Replikin Count(TM) = number of replikins per 100 aminoacids) examined by automated FluForecast(R) software found those areas of thetrypanosome genome which have the highest replikin concentrations (ReplikinPeak Genes(TM)).

Two instances of cyclical behavior were revealed in the trypanosome: thefirst cycle occurred from 1986 to 1995, and the second from 1996 to 2005. Thepeak of the first cycle, in 1987, with a Replikin Count(TM) of 38.2 +/-23.5,was followed by a higher peak in the next cycle, in 1999, of 62.9+/-63,exceeding 100 by overlap; both peaks were related to higher human mortality.Counts declined after the 1999 high to a low in 2005 of 7.4+/-6.5; and adecreased mortality rate followed between 2000 and 2005. A third malariareplikin cycle appears to have begun in 2007 with the Replikin Count(TM)increasing from 7.4+/-6.5 to 17.2+/-19; based on this information, the companyis predicting further increases in count and malaria mortality.

Cyclic increases in replikin concentration in the genome can be amechanism of expansion of an infectious organism into a territory. In otherexamples, the replikin concentration of West Nile Virus was earlier found toincrease annually through two distinct cycles as the virus expanded in theU.S.: the first from 2000 to 2003, and the second from 2004 to 2007 (p lessthan 0.001). Increases in the annual number of CDC reported human casesfollowed each of the virus replikin concentration increases. Similarcorrelations also have been shown for replikin concentrations and humanmortality in an influenza H5N1 cycle between 1997 and 2007.

Over the last 10 years, malaria has accounted for more than 10 milliondeaths worldwide -- by comparison, over the same period the H5N1 (Bird Flu)virus has been responsible for less than 300 human deaths. Consistent with thehigh replikin counts found in this study, trypanosomes have one of the highestreplication rates in nature. This property may account in part for theresistance of malaria to previous attempts at vaccination. The discovery ofthe relation of the replikins to rapid replication offers a new approach, andthe means, to inhibit rapid replication and limit mortality in malaria.

This release was issued through eReleases(TM). For more information,visit http://www.ereleases.com.Contact: Replikins Ltd., 38 The Fenway, Boston, MA 02215 email: sbogoch@replikins.com Tel: 646-320-5910 http://www.Replikins.com

SOURCE Replikins Ltd.


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