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Global D-Amino Acids Market

Wednesday, September 17, 2014 Corporate News
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LONDON, Sept. 16, 2014 /PRNewswire/ -- This report analyzes the worldwide markets for D-Amino Acids in US$ Thousands by the following End-Use Applications: Industrial, Pharmaceutical, and Others. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, The Middle East, and Latin America. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 37 companies including many key and niche players such as - Adisseo France S.A.SAjinomoto Co., Inc.AnaSpec, Inc.Evonik Industries AGIRIS Biotech GmbH
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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONSStudy Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-2Quantitative Techniques & Analytics I-3Product Definitions and Scope of Study I-3II. EXECUTIVE SUMMARY1. MARKET OVERVIEW II-1D-Amino Acids: A Promising Field with Potential Applications II-1D-Amino Acids: An Essential Raw Material for Pharmaceuticalsand Fine Chemicals Production II-1Developing Regions to Lend Traction to the Market Growth II-1Pharmaceuticals - The Largest End-use Sector for D-Amino Acids II-2Growing Prominence of Artificial Amino Acids to Drive MarketGrowth II-2
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2. AMINO ACIDS - GLOBAL OVERVIEW II-3Amino Acids - Essential Building Blocks of Proteins II-3Table 1: Global Amino Acids Market (2012): PercentageBreakdown of Value Sales by End-Use Segment (includescorresponding Graph/Chart) II-3Amino Acids - A Historical Perspective II-3Market Slows Down During 2007-2009 Economic Recession,Recovers in 2010 II-4Market Growth Stands Tempered Once Again Due to SlowingEconomy, But Optimism Prevails II-4Price Volatility Characterizes the Amino Acids Market II-5Table 2: Methionine Market: Average Market Price in (US$/Kg)in US & Western European Markets for 2010, 2011 & 2012(includes corresponding Graph/Chart) II-5Table 3: Global Threonine Market: Average Market Price in(US$/Kg) for 2010, 2011 & 2012 (includes correspondingGraph/Chart) II-6Table 4: Global Tryptophan Market: Average Market Price in(US$/Kg) for 2010, 2011 & 2012 (includes correspondingGraph/Chart) II-6Methionine - The Traditional Revenue Contributor to theOverall Amino Acids Market II-6Table 5: Global Methionine Market (2013): Percentage ShareBreakdown of Volume Consumption by Region (includescorresponding Graph/Chart) II-7Key Statistics II-7Table 6: Global Lysine Market (2013): Percentage ShareBreakdown of Volume Consumption by Region (includescorresponding Graph/Chart) II-7

Table 7: Global Threonine Market (2013): Percentage ShareBreakdown of Volume Consumption by Region (includescorresponding Graph/Chart) II-8Table 8: Global Tryptophan Market (2013): Percentage ShareBreakdown of Volume Consumption by Region (includescorresponding Graph/Chart) II-8Competition II-8M&A Activity to Spur Growth II-8Significance of Research Activities in Amino Acids Market II-8Methionine Market - Oligopolistic in Nature II-9Table 9: Leading Players in the Global DL-Methionine Market(2012): Percentage Breakdown of Production Capacities byLeading Players (includes corresponding Graph/Chart) II-9Other Key Market Share Findings II-10Table 10: Global Threonine Market (2012): Percentage MarketShare Breakdown of Leading Players (includes correspondingGraph/Chart) II-10Table 11: Global Tryptophane Market (2012): Percentage MarketShare Breakdown of Leading Players (includes correspondingGraph/Chart) II-10

3. MARKET TRENDS, DRIVERS & ISSUES II-11Aging World Population Drives the Demand for D-Amino Acids II-11Table 12: Global Population Statistics for the 65+ Age Group(2013) (includes corresponding Graph/Chart) II-12Table 13: Elderly Population (65+ Years) as a % of TotalPopulation (2000 & 2025) (includes corresponding Graph/Chart) II-13Table 14: Percentage of Population Aged 65 and Above in EU-27Countries, US and Japan (1960-2030) (includes correspondingGraph/Chart) II-13Table 15: Life Expectancy for Select Countries in Number ofYears (2013) (includes corresponding Graph/Chart) II-14Table 16: Life Expectancy Rates at Birth by Geographic Region(1990 & 2011) (includes corresponding Graph/Chart) II-15Alanine Racemase Chiral Analogue (ARCA): A Breakthrough ChiralConverting Agent for Amino Acids II-15Development of a New Approach for Switching Chirality in AminoAcids II-16Genetic Engineering and Advances in Research Enable DAAO Usein Multiple Arenas II-16Commercial Development of ARCA II-16Need for More Research in the D-Amino Acids Market II-16Growing Interest in Peptide Research Drives D-Amino Acids Market II-17Pharmaceutical Intermediates Market Challenged by DrugDevelopment II-17

4. D-AMINO ACIDS: AN OVERVIEW OF PRESENT APPLICATIONS AND FUTUREPOTENTIAL II-18D-Amino Acids Applications in the Pharmaceutical Sector II-18Select D-Amino Acids and their Diverse Applications II-18Optically Pure D-Amino Acids and their PharmaceuticalApplications II-19Optically Active Peptides and Neuropeptides Containing D-phenylalanine II-19Overview of Select D-Amino Acids Used in PharmaceuticalApplications II-20D-Arginine II-20D-Glutamine II-20D-Methionine, D-Leucine, D-Threonine, and D-Alanine II-20D-Methionine-Pyruvate Transaminase II-20D-Valine II-20D-Aspartic Acid II-21D-alpha-Aminoadipic acid (DAA) II-21D-Ornithine II-21(R)-6-Oxo-Pipecolic Acid II-21A Note on Ionic Liquids II-21Poly-D-amino Acids II-21D-Amino Acids Used in Antibiotics Production II-22D-Amino Acids Use in Peptide Design II-22D-Amino Acids Applications in the Industrial Sector II-22D-Amino Acids in Foods II-22D-Amino Acids in Food Flavorants II-22D-Amino Acids in Artificial Sweeteners (Alitame) II-23D-Amino Acids in Deodorants II-23D-Amino-Acids in Insecticides II-235. PRODUCT OVERVIEW II-24What do Amino Acids Do? II-24Key Functions of Amino Acids II-24Essential Vs. Non-Essential Amino Acids II-24Different Amino Acids and their Biological Functions II-25Structure and Composition of Amino Acids II-25Commercial Production of Natural Amino Acids II-26Fermentation Method (Microbial Process) II-26Enzymatic Method (Chemical Process) II-26Extraction Method II-26What are L and D Amino Acids? II-26Introduction to D-amino Acids II-27Commercial Production of D-Amino Acids II-27Fermentation Process is Not Applicable for CommercialProduction of D-Amino Acids II-27Alternative Methods of Enzymatic Preparation of D-Amino Acids II-28Use of Immobilized Enzymes II-28

6. RESEARCH AND DEVELOPMENT IN D-AMINO ACIDS ARENA II-29D-Amino Acids and DAAO in Immunology and Therapeutics II-29D-Amino Acids and their Role in Immunity II-29Potential Therapeutic Role of D-Amino Acid Oxidase inSchizophrenia II-29Study on In Situ Hybridization and ImmunohistochemicalActivity of DAAO: A Review II-29Study on Immunoreactivity and Immunohistochemical Activity ofd-Serine: A Review II-30Observations and Inference II-30DAAO in Leukocytes: Effective Treatment Against CertainMicrorganisms II-30D-Amino Acids in Biotechnology II-31Application of Biotechnology to Enable Use of D-amino acidas N-source by Plants II-31D-Amino Acid Oxidase (DAAO) Selectable Marker System II-31Positive Selection II-32Negative Selection II-32Biosensor for D-Amino Acids II-32DAAO: The Most Widely Studied D-Amino Acids Associated Enzyme II-32Occurrence and Distribution II-32Physiological Role of DAAO in Eukaryotes II-33Early Studies and Progress in DAAO in the Subsequent Decade II-33Advances in Genetic Engineering Fuelled DAAO Research II-33Research Unlocks the Potential for DAAO Use in Multiple Arenas II-33Research Findings for D-Amino Acids in Natural and ProcessedFoods II-34Research Findings on Select D-Amino Acids Used in Diet (Datais Based on Animal Studies) II-34Processed Foods: A Source of D-Amino Acids II-35What Induces the Formation of D-Amino Acids in Processed Foods? II-35What is the Impact? II-35Racemisation of Essential Amino Acids II-35D-Amino Acids in Milk and Milk Products II-35Occurrence of D-Amino Acids in Select Natural and ProcessedFoods II-36Table 17: D-Aspartic Acid Content of Select Milk Productsin Comparison To Untreated Milk (includes correspondingGraph/Chart) II-37

Table 18: Comparison of Select Free Amino Acid Compositionof Raw Milk with Fermented Milk (includes correspondingGraph/Chart) II-37Content of Select D-Amino Acids in Select Processed Foods II-38Cheese II-38Table 19: Content of Select D-Amino Acids in DifferentVarieties of Cheese (in milimol/100g): A Comparison(includes corresponding Graph/Chart) II-38Table 20: Content of Select D-Amino Acids in DifferentVarieties of Cheese (in %): A Comparison (includescorresponding Graph/Chart) II-39Table 21: Percentage Content of Select D-Amino Acids inBread and Toast (includes corresponding Graph/Chart) II-40Table 22: Percentage Content of Select D-Amino Acids in SoyaBean Meal and Extruded Soya Bean Meal (includescorresponding Graph/Chart) II-40Table 23: Percentage Content of Select D-Amino Acids inUntreated Soya Protein and Soya Protein (includescorresponding Graph/Chart) II-41Table 24: Percentage Content of Select D-Amino Acids in RawMeat and Ham Burger (includes corresponding Graph/Chart) II-41Table 25: Percentage of Select D-Amino Acids in Raw Chickenand Chicken Muscle (includes corresponding Graph/Chart) II-42Table 26: Percentage Content of Select D-Amino Acids inBacon and Heat Treated Bacon (includes correspondingGraph/Chart) II-42Table 27: Percentage Content of Select D-Amino Acids inCasein and Heat Treated Casein (includes correspondingGraph/Chart) II-43

7. INNOVATIONS AND DEVELOPMENTS IN D-AMINO ACIDS SPACE II-44Ajinomoto Develops Ajiphase and Corynex Amino Acid SynthesisTechnologies II-44Harvard University's Scientists Discover New BiofilmDisrupting Bacteria II-44Aminologics Conclude Large Scale Pilot Tests of Two D-AminoAcids with Novel ARCA Technology II-44Study Reveals that D-Amino Acids Amass in EMCs II-45Research Studies Suggests that Replacement of One L-Amino Acidwith Analogous D-enantiomer Results in High Therapeutic Index II-458. RECENT INDUSTRY ACTIVITY II-46AnaSpec Introduces Glycosylated (GlcNac) Serine and Threoninefor Synthesis of PTM Peptides II-46AnaSpec Rolls Out Two Rabbit Polyclonal Antibodies and FiveTau Peptides II-46Evonik Industries Develops New Process for Serine Synthesis II-46Evonik to Open New Production Facilities II-46

9. FOCUS ON SELECT PLAYERS II-47Adisseo France S.A.S (France) II-47Ajinomoto Co., Inc. (Japan) II-47AnaSpec, Inc. (US) II-47Evonik Industries AG (Germany) II-48IRIS Biotech GmbH (Germany) II-48LifeSpan Biosciences, Inc. (US) II-48Novus Biologicals LLC (US) II-49Sekisui Medical Co., Ltd. (Japan) II-49Shanghai Hanhong Chemical Co., Ltd. (China) II-49Sichuan Tongsheng Amino acid Co., Ltd. (China) II-50Sigma-Aldrich Corporation (US) II-50Sumitomo Chemicals America, Inc. (US) II-50TCI America, Inc. (US) II-51Tocris Bioscience (US) II-51Zhangjiagang Huachang Pharmaceutical Co., Ltd. (China) II-5110. GLOBAL MARKET PERSPECTIVE II-52Table 28: World Recent Past, Current & Future Analysis forD-Amino Acids by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, Middle East, and Latin America MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) II-52

Table 29: World Historic Review for D-Amino Acids byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,Middle East, and Latin America Markets Independently Analyzedwith Annual Sales Figures in US$ Thousand for Years 2006through 2012 (includes corresponding Graph/Chart) II-53Table 30: World 15-Year Perspective for D-Amino Acids byGeographic Region - Percentage Share Breakdown of Dollar Salesfor US, Canada, Japan, Europe, Asia-Pacific, Middle East, andLatin America Markets for Years 2006, 2014 and 2020 (includescorresponding Graph/Chart) II-54Table 31: World Recent Past, Current & Future Analysis forD-Amino Acids in Industrial End-Use Applications by GeographicRegion - US, Canada, Japan, Europe, Asia-Pacific, Middle East,and Latin America Markets Independently Analyzed with AnnualSales Figures in US$ Thousand for Years 2013 through 2020(includes corresponding Graph/Chart) II-55

Table 32: World Historic Review for D-Amino Acids inIndustrial End-Use Applications by Geographic Region - US,Canada, Japan, Europe, Asia-Pacific, Middle East, and LatinAmerica Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012 (includescorresponding Graph/Chart) II-56Table 33: World 15-Year Perspective for D-Amino Acids inIndustrial End-Use Applications by Geographic Region -Percentage Share Breakdown of Dollar Sales for US, Canada,Japan, Europe, Asia-Pacific, Middle East, and Latin AmericaMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-57Table 34: World Recent Past, Current & Future Analysis forD-Amino Acids in Pharmaceutical End-Use Applications byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,Middle East, and Latin America Markets Independently Analyzedwith Annual Sales Figures in US$ Thousand for Years 2013through 2020 (includes corresponding Graph/Chart) II-58Table 35: World Historic Review for D-Amino Acids inPharmaceutical End-Use Applications by Geographic Region - US,Canada, Japan, Europe, Asia-Pacific, Middle East, and LatinAmerica Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012 (includescorresponding Graph/Chart) II-59

Table 36: World 15-Year Perspective for D-Amino Acids inPharmaceutical End-Use Applications by Geographic Region -Percentage Share Breakdown of Dollar Sales for US, Canada,Japan, Europe, Asia-Pacific, Middle East, and Latin AmericaMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-60Table 37: World Recent Past, Current & Future Analysis forD-Amino Acids in Other End-Use Applications by GeographicRegion - US, Canada, Japan, Europe, Asia-Pacific, Middle East,and Latin America Markets Independently Analyzed with AnnualSales Figures in US$ Thousand for Years 2013 through 2020(includes corresponding Graph/Chart) II-61Table 38: World Historic Review for D-Amino Acids in OtherEnd-Use Applications by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, Middle East, and Latin America MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2006 through 2012 (includes correspondingGraph/Chart) II-62Table 39: World 15-Year Perspective for D-Amino Acids in OtherEnd-Use Applications by Geographic Region - Percentage ShareBreakdown of Dollar Sales for US, Canada, Japan, Europe,Asia-Pacific, Middle East, and Latin America Markets for Years2006, 2014 and 2020 (includes corresponding Graph/Chart) II-63

III. MARKET1. THE UNITED STATES III-1A.Market Analysis III-1Current & Future Analysis III-1Strategic Corporate Developments III-1Select Players III-1B.Market Analytics III-4Table 40: US Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-4Table 41: US Historic Review for D-Amino Acids by End-UseApplication - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-5Table 42: US 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-6

2. CANADA III-7Market Analysis III-7Table 43: Canadian Recent Past, Current & Future Analysisfor D-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-7Table 44: Canadian Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-8Table 45: Canadian 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-9

3. JAPAN III-10A.Market Analysis III-10Current & Future Analysis III-10Select Players III-10B.Market Analytics III-11Table 46: Japanese Recent Past, Current & Future Analysisfor D-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-11Table 47: Japanese Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-12Table 48: Japanese 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-13

4. EUROPE III-14Market Analysis III-14Table 49: European Recent Past, Current & Future Analysisfor D-Amino Acids by Geographic Region - France, Germany,Italy, UK, Spain, Russia and Rest of Europe MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) III-14Table 50: European Historic Review for D-Amino Acids byGeographic Region - France, Germany, Italy, UK, Spain,Russia and Rest of Europe Markets Independently Analyzedwith Annual Sales Figures in US$ Thousand for Years 2006through 2012 (includes corresponding Graph/Chart) III-15Table 51: European 15-Year Perspective for D-Amino Acids byGeographic Region - Percentage Share Breakdown of DollarSales for France, Germany, Italy, UK, Spain, Russia and Restof Europe Markets for Years 2006, 2014 & 2020 (includescorresponding Graph/Chart) III-16

Table 52: European Recent Past, Current & Future Analysisfor D-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-17Table 53: European Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-18Table 54: European 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-19

4a. FRANCE III-20A.Market Analysis III-20Current & Future Analysis III-20Adisseo France S.A.S - A Major French Player III-20B.Market Analytics III-21Table 55: French Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-21Table 56: French Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-22Table 57: French 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-23

4b. GERMANY III-24A.Market Analysis III-24Current & Future Analysis III-24Strategic Corporate Development III-24Select Players III-24B.Market Analytics III-25Table 58: German Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-25Table 59: German Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-26Table 60: German 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-27

4c. ITALY III-28Market Analysis III-28Table 61: Italian Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-28Table 62: Italian Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-29Table 63: Italian 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-30

4d. THE UNITED KINGDOM III-31Market Analysis III-31Table 64: UK Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-31Table 65: UK Historic Review for D-Amino Acids by End-UseApplication - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-32Table 66: UK 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-33

4e. SPAIN III-34Market Analysis III-34Table 67: Spanish Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-34Table 68: Spanish Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-35Table 69: Spanish 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-36

4f. RUSSIA III-37Market Analysis III-37Table 70: Russian Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-37Table 71: Russian Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-38Table 72: Russian 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-39

4g. REST OF EUROPE III-40Market Analysis III-40Table 73: Rest of Europe Recent Past, Current & FutureAnalysis for D-Amino Acids by End-Use Application -Industrial, Pharmaceutical and Other Application MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) III-40Table 74: Rest of Europe Historic Review for D-Amino Acidsby End-Use Application - Industrial, Pharmaceutical andOther Application Markets Independently Analyzed with AnnualSales Figures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-41Table 75: Rest of Europe 15-Year Perspective for D-AminoAcids by End-Use Application - Percentage Breakdown ofDollar Sales for Industrial, Pharmaceutical and OtherApplication Markets for Years 2006, 2014 & 2020 (includescorresponding Graph/Chart) III-42

5. ASIA-PACIFIC III-43Market Analysis III-43Table 76: Asia-Pacific Recent Past, Current & FutureAnalysis for D-Amino Acids by Geographic Region - China andRest of Asia-Pacific Markets Independently Analyzed withAnnual Sales Figures in US$ Thousand for Years 2013 through2020 (includes corresponding Graph/Chart) III-43Table 77: Asia-Pacific Historic Review for D-Amino Acids byGeographic Region - China and Rest of Asia-Pacific MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2006 through 2012 (includes correspondingGraph/Chart) III-44Table 78: Asia-Pacific 15-Year Perspective for D-Amino Acidsby Geographic Region - Percentage Breakdown of Dollar Salesfor China and Rest of Asia-Pacific Markets for Years 2006,2014 & 2020 (includes corresponding Graph/Chart) III-45

Table 79: Asia-Pacific Recent Past, Current & FutureAnalysis for D-Amino Acids by End-Use Application -Industrial, Pharmaceutical and Other Application MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) III-46Table 80: Asia-Pacific Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-47Table 81: Asia-Pacific 15-Year Perspective for D-Amino Acidsby End-Use Application - Percentage Breakdown of DollarSales for Industrial, Pharmaceutical and Other ApplicationMarkets for Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-48

5a. CHINA III-49A.Market Analysis III-49Current and Future Outlook III-49China Dominates the Global D-Amino Acids Market III-49Select Players III-49B.Market Analytics III-50Table 82: Chinese Recent Past, Current & Future Analysis forD-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-50Table 83: Chinese Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-51Table 84: Chinese 15-Year Perspective for D-Amino Acids byEnd-Use Application - Percentage Breakdown of Dollar Salesfor Industrial, Pharmaceutical and Other Application Marketsfor Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-52

5b. REST OF ASIA-PACIFIC III-53A.Market Analysis III-53Current & Future Analysis III-53Strategic Corporate Development III-53B.Market Analytics III-54Table 85: Rest of Asia-Pacific Recent Past, Current & FutureAnalysis for D-Amino Acids by End-Use Application -Industrial, Pharmaceutical and Other Application MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) III-54Table 86: Rest of Asia-Pacific Historic Review for D-AminoAcids by End-Use Application - Industrial, Pharmaceuticaland Other Application Markets Independently Analyzed withAnnual Sales Figures in US$ Thousand for Years 2006 through2012 (includes corresponding Graph/Chart) III-55Table 87: Rest of Asia-Pacific 15-Year Perspective forD-Amino Acids by End-Use Application - Percentage Breakdownof Dollar Sales for Industrial, Pharmaceutical and OtherApplication Markets for Years 2006, 2014 & 2020 (includescorresponding Graph/Chart) III-56

6. THE MIDDLE EAST III-57Market Analysis III-57Table 88: Middle East Recent Past, Current & Future Analysisfor D-Amino Acids by End-Use Application - Industrial,Pharmaceutical and Other Application Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Thousand for Years2013 through 2020 (includes corresponding Graph/Chart) III-57Table 89: Middle East Historic Review for D-Amino Acids byEnd-Use Application - Industrial, Pharmaceutical and OtherApplication Markets Independently Analyzed with Annual SalesFigures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-58Table 90: Middle East 15-Year Perspective for D-Amino Acidsby End-Use Application - Percentage Breakdown of DollarSales for Industrial, Pharmaceutical and Other ApplicationMarkets for Years 2006, 2014 & 2020 (includes correspondingGraph/Chart) III-59

7. LATIN AMERICA III-60Market Analysis III-60Table 91: Latin American Recent Past, Current & FutureAnalysis for D-Amino Acids by End-Use Application -Industrial, Pharmaceutical and Other Application MarketsIndependently Analyzed with Annual Sales Figures in US$Thousand for Years 2013 through 2020 (includes correspondingGraph/Chart) III-60Table 92: Latin American Historic Review for D-Amino Acidsby End-Use Application - Industrial, Pharmaceutical andOther Application Markets Independently Analyzed with AnnualSales Figures in US$ Thousand for Years 2006 through 2012(includes corresponding Graph/Chart) III-61Table 93: Latin American 15-Year Perspective for D-AminoAcids by End-Use Application - Percentage Breakdown ofDollar Sales for Industrial, Pharmaceutical and OtherApplication Markets for Years 2006, 2014 & 2020 (includescorresponding Graph/Chart) III-62

IV. COMPETITIVE LANDSCAPETotal Companies Profiled: 37 (including Divisions/Subsidiaries - 37)The United States (8)Japan (4)Europe (5)- France (1)- Germany (2)- Rest of Europe (2)Asia-Pacific (Excluding Japan) (20)

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