LONDON, Sept. 16, 2014 /PRNewswire/ -- This report analyzes the worldwide markets for Biocompatible Materials in US$ Million by the following Product Segments: Polymeric Materials, Metallic Materials, Natural Materials, and Other Materials. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 59 companies including many key and niche players such as - AdvanSource Biomaterials CorporationBASF CorporationBerkeley Advanced Biomaterials, Inc.Biomet, Inc.BioMimetic Therapeutics LLC
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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONSStudy Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-2Quantitative Techniques & Analytics I-3Product Definition and Scope of Study I-3Polymeric Materials I-3Metallic Materials I-4Natural Materials I-4Other Materials I-4II. EXECUTIVE SUMMARY1. INDUSTRY OVERVIEW II-1Biocompatible Materials - Transforming Medicine II-1Current and Future Analysis II-2Key Growth Drivers II-2Increasing R& D Investments - The Growth Impetus II-2Assessment of Worldwide R&D Activities in the Area ofBiomaterials II-3Technological Advancements Foster Growth for Biomaterials II-3Rising Prevalence of Arthritis and Other Orthopedic DisordersDrives Biomaterials Market II-4Developing Regions to Propel Future Growth II-4Ageing Population - A Perennial Growth Driver II-5Table 1: Elderly Population (60+ Years) as a Percentage ofthe Total Population (2012 & 2050) (includes correspondingGraph/Chart) II-5
Table 2: Global Aging Population by Age Group: 1975-2050(includes corresponding Graph/Chart) II-6Factors Determining Market Growth II-6Awareness of Basic Mechanisms of Cell-Material Interaction II-6Birth of Cross-Disciplinary Field of Tissue Engineering II-6Rise in Biomaterial Prices II-7Reimbursement Issues Haunt Biomaterial Market II-72. MARKET TRENDS & ISSUES II-8Entering the Era of Self-Healing - Next Generation ofBiomaterials II-8Tissue Engineering & Regenerative Medicine - The Next GrowthAvenues II-8Scaffolds for Tissue Engineering II-9Nanotechnology - Revolutionizing Development of BiomaterialImplants II-10Increasing Adoption of Medical Implants Fuels Demand II-11Table 3: Select Musculoskeletal Conditions - PercentageBreakdown by Age Group (includes corresponding Graph/Chart) II-11Table 4: Global Knee and Hip Implants Market (2013):Percentage Share Breakdown of Revenues by Category (includescorresponding Graph/Chart) II-12Bone Graft Procedures - Market Opportunity II-12Growing Use of Dental Biomaterials Aiding Market Growth II-12Natural Substances find Increasing Application in BiomaterialSyntheses II-13Biocompatible Coatings Playing an Indispensable Role II-13Active Coatings to Grow in Demand II-14Major Applications of Hemocompatible Coatings II-14Age of Bioabsorbable Stents II-15Wound Care Biologics Gain Prominence with Biomaterial Products II-15Advanced Ceramics Gain Preeminence in Regenerative Medicine Field II-16Orthobiologics Gain Traction in the Bone Grafts Market II-16Table 5: Global Orthobiologics Market (2012): PercentageBreakdown of Value Sales for Allograft & DBM, Blood &Marrow-based Products, Growth Factors, Hemostasis, SyntheticBone Graft Substitutes and Viscosupplements (includescorresponding Graph/Chart) II-17
Table 6: Leading Players in the Global Orthobiologics Market(2013): Percentage Breakdown of Value Sales for Baxter,J&J/Synthes, Medtronic, Sanofi, Stryker and Others (includescorresponding Graph/Chart) II-18Future Directions - Insight into Select Areas of Research II-18Use of Photopolymerizable Polymers II-18Electrically Conductive Polymers II-18Protein-based Biomaterials II-18Advanced Hydrogels II-19Biodegradable Scaffolds II-19Immuno-modulatory Biomaterials II-19Collagen - An Efficient Biomaterial for Synthetic Vascular Grafts II-20Chitin as a New Biomaterial II-203. PRODUCT OVERVIEW II-21Biocompatible Materials - An Introduction II-21Changing Definition of Biomaterials II-21Definition of biocompatibility- Then and Now II-21Evolution of Biocompatible Material Science II-22Important Milestones in Biomaterials Evolution II-22Product Segments II-23Polymeric Materials II-23Hydrogels II-23Biodegradable Polymers II-23Metallic Materials II-24Natural Materials II-25Collagen II-25Hyaluronic Acid II-25Other Materials II-25Ceramics II-25Bioactive Ceramics II-26Composites II-26Pyrolitic Carbon II-26List of Technological Issues of Natural Biomaterials II-27List of Few Technological Issues of Other BiomaterialCategories II-27Applications of Biocompatible Materials II-28Biomaterials Categories and their Applications II-28List of Biomaterial Applications with respect to Medical Problem II-28Biomaterial Applications with respect to Organ II-28Biomaterial Applications with respect to Body Systems II-29Biomaterial Segments and Applications: An Outline II-29
4. THERAPEUTIC AREAS - OPPORTUNITIES AND TRENDS II-30Orthopedics II-30Innovations in Orthopedic Biomaterials: A Glance II-30Synthetic Bone Grafts II-30Combination of Bone Marrow and Bone Graft Substitute II-30Demineralized Bone Matrices (DBMs) Market: Strong Growth butTough Competition II-31Bone Morphogenetic Proteins II-31GEM OS®1 Shows Promise II-32geneX® Synthetic Bone Graft Substitute II-32BoneCure Sleeve - Heading Towards the Human Market II-32Bioactive Glass - Suitable for Weight Bearing Portion II-32Tissue Engineered Cartilages - A Promising Solution forCartilage Repair II-32Stem Cells to Support Tissue Engineering II-33Cardiovascular Devices II-33Stents II-34Heart Valves II-34Move towards Bioprosthetic Valves II-35PTCA Devices II-35Ventricular Assist Device II-36Artificial Blood Vessels II-36Artificial Blood II-36Urology II-36Dialysis II-37Dermatology and Wound Care II-37Surgery II-37Biomaterials Mark Metamorphosis in Surgical Incision ClosureMarket II-37High Strength Surgical Adhesives Garner Growth with Biomaterials II-38Orthodontics II-38Nano-technology in Dental Fillings and Implants II-38Biomaterials for Cosmetic Formulations II-39Neurology II-39Electrodes II-39Biomaterials in Ophthalmology II-39Materials for Drug Delivery Systems II-40Polyethylene Glycol as a Drug Delivery System II-40Hydrogels as Drug Delivery System II-40Vinylic based Drug Delivery Systems II-40Collagen Based Drug Delivery System II-405. REGULATORY ENVIRONMENT II-41FDA Regulations II-41American Society for Testing and Materials (ASTM) II-41Joint Research Center (JRC) II-41Biocompatibility Testing of Materials II-41Testing Levels II-41General Biocompatibility Testing II-41Individual Biocompatibility Testing II-42Testing Methods II-42
6. RECENT INDUSTRY ACTIVITY II-43Amedica Corporation Ceases Biologic Distribution Agreement II-43Glass Technology Services and Fame-Med Medical Trade Partnersto Develop Biocompatible Glass Ceramics II-43InCube Labs Enters into Agreement with Engineering ResearchCenter II-43Regentis Biomaterials Obtains CE Mark Approval for GelrinC II-43Olympus Biotech International and BonAlive Biomaterials Enterinto Distribution Agreement II-43Invibio Biomaterial Solutions to Introduce PEEK-Optima HAEnhanced II-43Coreleader Biotech Develops Novel Method for BiocompatiblePolymeric Fibre Manufacturing II-44Purac Biomaterials to Construct a New Manufacturing Facility II-44PetVivo Holdings Enters into Binding Term Sheet with Gel-DelTechnologies for Merger II-44
7. FOCUS ON SELECT PLAYERS II-45AdvanSource Biomaterials Corporation (US) II-45BASF Corporation (US) II-45Berkeley Advanced Biomaterials, Inc. (US) II-45Biomet, Inc. (US) II-46BioMimetic Therapeutics LLC (US) II-46BonAlive Biomaterials, Ltd. (Finland) II-47Cam Bioceramics BV (Netherlands) II-47Celanese Corporation (US) II-47Corbion Purac (Netherlands) II-48Evonik Industries AG (Germany) II-48Exactech, Inc. (US) II-49Hycail Finland OY (Finland) II-49Invibio Biomaterial Solutions (UK) II-49Morgan Technical Ceramics (UK) II-50Nobel Biomaterials, Inc. (US) II-50Royal DSM N.V. (The Netherlands) II-50Stryker Corporation (US) II-51
8. GLOBAL MARKET PERSPECTIVE II-52Table 7: World Recent Past, Current and Future Analysis forBiocompatible Materials by Geographic Region - US, Canada,Japan, Europe, Asia-Pacific, and Rest of World MarketsIndependently Analyzed with Annual Sales Figures in US$Million for Years 2013 through 2020 (includes correspondingGraph/Chart) II-52Table 8: World Historic Review for Biocompatible Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-53Table 9: World 15-Year Perspective for Biocompatible Materialsby Geographic Region - Percentage Breakdown of Dollar Salesfor US, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-54
Table 10: World Recent Past, Current and Future Analysis forPolymeric Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-55Table 11: World Historic Review for Polymeric Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-56Table 12: World 15-Year Perspective for Polymeric Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-57
Table 13: World Recent Past, Current and Future Analysis forMetallic Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-58Table 14: World Historic Review for Metallic Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-59Table 15: World 15-Year Perspective for Metallic Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-60
Table 16: World Recent Past, Current and Future Analysis forNatural Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-61Table 17: World Historic Review for Natural Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-62Table 18: World 15-Year Perspective for Natural Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-63
Table 19: World Recent Past, Current and Future Analysis forOther Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-64Table 20: World Historic Review for Other Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-65Table 21: World 15-Year Perspective for Other Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-66
III. MARKET1. THE UNITED STATES III-1A.Market Analysis III-1Current and Future Analysis III-1Orthopedic Biomaterials Market - An Overview III-1Bone Graft Substitutes Market: Opportunities for Growth III-1Growth in Regenerative Medicine Augers Well III-2Implantable Regenerative Products Take Over Sports Medicine III-2Cardiovascular Devices - A Potential Growth Market III-3Regulatory Environment III-3FDA Regulations III-3Regulatory Challenges Limit Growth in the US OrthopedicBiomaterials Market III-4Recent Industry Activity III-4Select Players III-5B.Market Analytics III-9Table 22: The US Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-9Table 23: The US Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-10Table 24: The US 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-11
2. CANADA III-12A.Market Analysis III-12Regenerative Medicine - An Advanced Market III-12Favorable Growth Prospects in Bone Graft Substitutes Market III-12B.Market Analytics III-13Table 25: Canadian Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-13Table 26: Canadian Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-14Table 27: Canadian 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-15
3. JAPAN III-16A.Market Analysis III-16Current and Future Analysis III-16An Overview III-16Import Scenario: Implants III-16Table 28: Japanese Percentage Imports by Implant Type(includes corresponding Graph/Chart) III-17Orthopedic Biomaterials Market III-17Market for Cardiovascular Devices III-17B.Market Analytics III-18Table 29: Japanese Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-18Table 30: Japanese Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-19Table 31: Japanese 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-20
4. EUROPE III-21A.Market Analysis III-21Current and Future Analysis III-21Orthopedic Biomaterials Market III-21Synthetic Bone Graft Market Drives the BGS Market III-22Dental Biomaterials Market in Europe: An Insight III-22Cardiovascular Devices Market - Highly Diverse Europe III-22Great Potential for Regenerative Medicine III-23Regulatory Environment III-23Government Regulations III-23Key Players in Select Segments III-24Table 32: European Market for Demineralized Bone Matrix byLeading Companies/Organizations (2012): Percentage MarketShare Breakdown of Value Sales for Medtronic,Musculoskeletal Transplant Foundation, RTI Surgical, WrightMedical Technology and Others (includes correspondingGraph/Chart) III-24Recent Industry Activity III-24B.Market Analytics III-25Table 33: European Recent Past, Current and Future Analysisfor Biocompatible Materials by Geographic Region - France,Germany, Italy, UK, and Rest of Europe Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) III-25Table 34: European Historic Review for BiocompatibleMaterials by Geographic Region - France, Germany, Italy, UK,and Rest of Europe Markets Independently Analyzed withAnnual Sales Figures in US$ Million for Years 2006 through2012 (includes corresponding Graph/Chart) III-26Table 35: European 15-Year Perspective for BiocompatibleMaterials by Geographic Region - Percentage Breakdown ofDollar Sales for France, Germany, Italy, UK, and Rest ofEurope Markets for Years 2006, 2014 and 2020 (includescorresponding Graph/Chart) III-27
Table 36: European Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-28Table 37: European Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-29Table 38: European 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-30
4a. FRANCE III-31Market Analysis III-31Table 39: French Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-31Table 40: French Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-32Table 41: French 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-33
4b. GERMANY III-34A.Market Analysis III-34Current and Future Analysis III-34Evonik Industries AG - A Key Player III-34B.Market Analytics III-35Table 42: German Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-35Table 43: German Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-36Table 44: German 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-37
4c. ITALY III-38Market Analysis III-38Table 45: Italian Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-38Table 46: Italian Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-39Table 47: Italian15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-40
4d. THE UNITED KINGDOM III-41A.Market Analysis III-41Current and Future Analysis III-41Implants Product Innovations are focused on Biomaterials III-41Recent Industry Activity III-41Select Players III-41B.Market Analytics III-43Table 48: UK Recent Past, Current and Future Analysis forBiocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-43Table 49: UK Historic Review for Biocompatible Materials byType - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-44Table 50: UK 15-Year Perspective for Biocompatible Materialsby Type - Percentage Breakdown of Dollar Sales for PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets for Years 2006, 2014 and 2020 (includescorresponding Graph/Chart) III-45
4e. REST OF EUROPE III-46A.Market Analysis III-46Current and Future Analysis III-46Recent Industry Activity III-46Select Players III-46B.Market Analytics III-49Table 51: Rest of Europe Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-49Table 52: Rest of Europe Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-50Table 53: Rest of Europe 15-Year Perspective forBiocompatible Materials by Type - Percentage Breakdown ofDollar Sales for Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets for Years2006, 2014 and 2020 (includes corresponding Graph/Chart) III-51
5. ASIA-PACIFIC III-52A.Market Analysis III-52Current and Future Analysis III-52Dental Bone Graft Substitutes and Biomaterials Market - AnOverview III-52Table 54: Over 65 Years Individuals as % of TotalPopulation in Select Asian Countries (2012) (includescorresponding Graph/Chart) III-52Focus on Select Regions III-53China III-53Biomaterials Market Overview III-53The Largest Biomaterial Research Country III-53Orthopedic Biomaterials Market III-53India III-53Orthopedic Biomaterials Market III-53Rise in Medical Tourism Drives Biomaterials Market III-54Attractive Market for Prosthetic Heart Valves DeviceManufacturers III-54B.Market Analytics III-55Table 55: Asia-Pacific Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-55Table 56: Asia-Pacific Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-56Table 57: Asia-Pacific 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-57
6. REST OF WORLD III-58A.Market Analysis III-58Current and Future Analysis III-58Brazilian Biomaterial Market - Overview III-58B.Market Analytics III-59Table 58: Rest of World Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-59Table 59: Rest of World Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-60Table 60: Rest of World 15-Year Perspective forBiocompatible Materials by Type - Percentage Breakdown ofDollar Sales for Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets for Years2006, 2014 and 2020 (includes corresponding Graph/Chart) III-61
IV. COMPETITIVE LANDSCAPETotal Companies Profiled: 59 (including Divisions/Subsidiaries - 64)The United States (41)Japan (2)Europe (19)- France (1)- Germany (2)- The United Kingdom (5)- Rest of Europe (11)Asia-Pacific (Excluding Japan) (1)Middle East (1)
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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONSStudy Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-2Quantitative Techniques & Analytics I-3Product Definition and Scope of Study I-3Polymeric Materials I-3Metallic Materials I-4Natural Materials I-4Other Materials I-4II. EXECUTIVE SUMMARY1. INDUSTRY OVERVIEW II-1Biocompatible Materials - Transforming Medicine II-1Current and Future Analysis II-2Key Growth Drivers II-2Increasing R& D Investments - The Growth Impetus II-2Assessment of Worldwide R&D Activities in the Area ofBiomaterials II-3Technological Advancements Foster Growth for Biomaterials II-3Rising Prevalence of Arthritis and Other Orthopedic DisordersDrives Biomaterials Market II-4Developing Regions to Propel Future Growth II-4Ageing Population - A Perennial Growth Driver II-5Table 1: Elderly Population (60+ Years) as a Percentage ofthe Total Population (2012 & 2050) (includes correspondingGraph/Chart) II-5
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Table 2: Global Aging Population by Age Group: 1975-2050(includes corresponding Graph/Chart) II-6Factors Determining Market Growth II-6Awareness of Basic Mechanisms of Cell-Material Interaction II-6Birth of Cross-Disciplinary Field of Tissue Engineering II-6Rise in Biomaterial Prices II-7Reimbursement Issues Haunt Biomaterial Market II-72. MARKET TRENDS & ISSUES II-8Entering the Era of Self-Healing - Next Generation ofBiomaterials II-8Tissue Engineering & Regenerative Medicine - The Next GrowthAvenues II-8Scaffolds for Tissue Engineering II-9Nanotechnology - Revolutionizing Development of BiomaterialImplants II-10Increasing Adoption of Medical Implants Fuels Demand II-11Table 3: Select Musculoskeletal Conditions - PercentageBreakdown by Age Group (includes corresponding Graph/Chart) II-11Table 4: Global Knee and Hip Implants Market (2013):Percentage Share Breakdown of Revenues by Category (includescorresponding Graph/Chart) II-12Bone Graft Procedures - Market Opportunity II-12Growing Use of Dental Biomaterials Aiding Market Growth II-12Natural Substances find Increasing Application in BiomaterialSyntheses II-13Biocompatible Coatings Playing an Indispensable Role II-13Active Coatings to Grow in Demand II-14Major Applications of Hemocompatible Coatings II-14Age of Bioabsorbable Stents II-15Wound Care Biologics Gain Prominence with Biomaterial Products II-15Advanced Ceramics Gain Preeminence in Regenerative Medicine Field II-16Orthobiologics Gain Traction in the Bone Grafts Market II-16Table 5: Global Orthobiologics Market (2012): PercentageBreakdown of Value Sales for Allograft & DBM, Blood &Marrow-based Products, Growth Factors, Hemostasis, SyntheticBone Graft Substitutes and Viscosupplements (includescorresponding Graph/Chart) II-17
Table 6: Leading Players in the Global Orthobiologics Market(2013): Percentage Breakdown of Value Sales for Baxter,J&J/Synthes, Medtronic, Sanofi, Stryker and Others (includescorresponding Graph/Chart) II-18Future Directions - Insight into Select Areas of Research II-18Use of Photopolymerizable Polymers II-18Electrically Conductive Polymers II-18Protein-based Biomaterials II-18Advanced Hydrogels II-19Biodegradable Scaffolds II-19Immuno-modulatory Biomaterials II-19Collagen - An Efficient Biomaterial for Synthetic Vascular Grafts II-20Chitin as a New Biomaterial II-203. PRODUCT OVERVIEW II-21Biocompatible Materials - An Introduction II-21Changing Definition of Biomaterials II-21Definition of biocompatibility- Then and Now II-21Evolution of Biocompatible Material Science II-22Important Milestones in Biomaterials Evolution II-22Product Segments II-23Polymeric Materials II-23Hydrogels II-23Biodegradable Polymers II-23Metallic Materials II-24Natural Materials II-25Collagen II-25Hyaluronic Acid II-25Other Materials II-25Ceramics II-25Bioactive Ceramics II-26Composites II-26Pyrolitic Carbon II-26List of Technological Issues of Natural Biomaterials II-27List of Few Technological Issues of Other BiomaterialCategories II-27Applications of Biocompatible Materials II-28Biomaterials Categories and their Applications II-28List of Biomaterial Applications with respect to Medical Problem II-28Biomaterial Applications with respect to Organ II-28Biomaterial Applications with respect to Body Systems II-29Biomaterial Segments and Applications: An Outline II-29
4. THERAPEUTIC AREAS - OPPORTUNITIES AND TRENDS II-30Orthopedics II-30Innovations in Orthopedic Biomaterials: A Glance II-30Synthetic Bone Grafts II-30Combination of Bone Marrow and Bone Graft Substitute II-30Demineralized Bone Matrices (DBMs) Market: Strong Growth butTough Competition II-31Bone Morphogenetic Proteins II-31GEM OS®1 Shows Promise II-32geneX® Synthetic Bone Graft Substitute II-32BoneCure Sleeve - Heading Towards the Human Market II-32Bioactive Glass - Suitable for Weight Bearing Portion II-32Tissue Engineered Cartilages - A Promising Solution forCartilage Repair II-32Stem Cells to Support Tissue Engineering II-33Cardiovascular Devices II-33Stents II-34Heart Valves II-34Move towards Bioprosthetic Valves II-35PTCA Devices II-35Ventricular Assist Device II-36Artificial Blood Vessels II-36Artificial Blood II-36Urology II-36Dialysis II-37Dermatology and Wound Care II-37Surgery II-37Biomaterials Mark Metamorphosis in Surgical Incision ClosureMarket II-37High Strength Surgical Adhesives Garner Growth with Biomaterials II-38Orthodontics II-38Nano-technology in Dental Fillings and Implants II-38Biomaterials for Cosmetic Formulations II-39Neurology II-39Electrodes II-39Biomaterials in Ophthalmology II-39Materials for Drug Delivery Systems II-40Polyethylene Glycol as a Drug Delivery System II-40Hydrogels as Drug Delivery System II-40Vinylic based Drug Delivery Systems II-40Collagen Based Drug Delivery System II-405. REGULATORY ENVIRONMENT II-41FDA Regulations II-41American Society for Testing and Materials (ASTM) II-41Joint Research Center (JRC) II-41Biocompatibility Testing of Materials II-41Testing Levels II-41General Biocompatibility Testing II-41Individual Biocompatibility Testing II-42Testing Methods II-42
6. RECENT INDUSTRY ACTIVITY II-43Amedica Corporation Ceases Biologic Distribution Agreement II-43Glass Technology Services and Fame-Med Medical Trade Partnersto Develop Biocompatible Glass Ceramics II-43InCube Labs Enters into Agreement with Engineering ResearchCenter II-43Regentis Biomaterials Obtains CE Mark Approval for GelrinC II-43Olympus Biotech International and BonAlive Biomaterials Enterinto Distribution Agreement II-43Invibio Biomaterial Solutions to Introduce PEEK-Optima HAEnhanced II-43Coreleader Biotech Develops Novel Method for BiocompatiblePolymeric Fibre Manufacturing II-44Purac Biomaterials to Construct a New Manufacturing Facility II-44PetVivo Holdings Enters into Binding Term Sheet with Gel-DelTechnologies for Merger II-44
7. FOCUS ON SELECT PLAYERS II-45AdvanSource Biomaterials Corporation (US) II-45BASF Corporation (US) II-45Berkeley Advanced Biomaterials, Inc. (US) II-45Biomet, Inc. (US) II-46BioMimetic Therapeutics LLC (US) II-46BonAlive Biomaterials, Ltd. (Finland) II-47Cam Bioceramics BV (Netherlands) II-47Celanese Corporation (US) II-47Corbion Purac (Netherlands) II-48Evonik Industries AG (Germany) II-48Exactech, Inc. (US) II-49Hycail Finland OY (Finland) II-49Invibio Biomaterial Solutions (UK) II-49Morgan Technical Ceramics (UK) II-50Nobel Biomaterials, Inc. (US) II-50Royal DSM N.V. (The Netherlands) II-50Stryker Corporation (US) II-51
8. GLOBAL MARKET PERSPECTIVE II-52Table 7: World Recent Past, Current and Future Analysis forBiocompatible Materials by Geographic Region - US, Canada,Japan, Europe, Asia-Pacific, and Rest of World MarketsIndependently Analyzed with Annual Sales Figures in US$Million for Years 2013 through 2020 (includes correspondingGraph/Chart) II-52Table 8: World Historic Review for Biocompatible Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-53Table 9: World 15-Year Perspective for Biocompatible Materialsby Geographic Region - Percentage Breakdown of Dollar Salesfor US, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-54
Table 10: World Recent Past, Current and Future Analysis forPolymeric Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-55Table 11: World Historic Review for Polymeric Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-56Table 12: World 15-Year Perspective for Polymeric Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-57
Table 13: World Recent Past, Current and Future Analysis forMetallic Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-58Table 14: World Historic Review for Metallic Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-59Table 15: World 15-Year Perspective for Metallic Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-60
Table 16: World Recent Past, Current and Future Analysis forNatural Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-61Table 17: World Historic Review for Natural Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-62Table 18: World 15-Year Perspective for Natural Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-63
Table 19: World Recent Past, Current and Future Analysis forOther Materials by Geographic Region - US, Canada, Japan,Europe, Asia-Pacific, and Rest of World Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) II-64Table 20: World Historic Review for Other Materials byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific,and Rest of World Markets Independently Analyzed with AnnualSales Figures in US$ Million for Years 2006 through 2012(includes corresponding Graph/Chart) II-65Table 21: World 15-Year Perspective for Other Materials byGeographic Region - Percentage Breakdown of Dollar Sales forUS, Canada, Japan, Europe, Asia-Pacific, and Rest of WorldMarkets for Years 2006, 2014 and 2020 (includes correspondingGraph/Chart) II-66
III. MARKET1. THE UNITED STATES III-1A.Market Analysis III-1Current and Future Analysis III-1Orthopedic Biomaterials Market - An Overview III-1Bone Graft Substitutes Market: Opportunities for Growth III-1Growth in Regenerative Medicine Augers Well III-2Implantable Regenerative Products Take Over Sports Medicine III-2Cardiovascular Devices - A Potential Growth Market III-3Regulatory Environment III-3FDA Regulations III-3Regulatory Challenges Limit Growth in the US OrthopedicBiomaterials Market III-4Recent Industry Activity III-4Select Players III-5B.Market Analytics III-9Table 22: The US Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-9Table 23: The US Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-10Table 24: The US 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-11
2. CANADA III-12A.Market Analysis III-12Regenerative Medicine - An Advanced Market III-12Favorable Growth Prospects in Bone Graft Substitutes Market III-12B.Market Analytics III-13Table 25: Canadian Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-13Table 26: Canadian Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-14Table 27: Canadian 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-15
3. JAPAN III-16A.Market Analysis III-16Current and Future Analysis III-16An Overview III-16Import Scenario: Implants III-16Table 28: Japanese Percentage Imports by Implant Type(includes corresponding Graph/Chart) III-17Orthopedic Biomaterials Market III-17Market for Cardiovascular Devices III-17B.Market Analytics III-18Table 29: Japanese Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-18Table 30: Japanese Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-19Table 31: Japanese 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-20
4. EUROPE III-21A.Market Analysis III-21Current and Future Analysis III-21Orthopedic Biomaterials Market III-21Synthetic Bone Graft Market Drives the BGS Market III-22Dental Biomaterials Market in Europe: An Insight III-22Cardiovascular Devices Market - Highly Diverse Europe III-22Great Potential for Regenerative Medicine III-23Regulatory Environment III-23Government Regulations III-23Key Players in Select Segments III-24Table 32: European Market for Demineralized Bone Matrix byLeading Companies/Organizations (2012): Percentage MarketShare Breakdown of Value Sales for Medtronic,Musculoskeletal Transplant Foundation, RTI Surgical, WrightMedical Technology and Others (includes correspondingGraph/Chart) III-24Recent Industry Activity III-24B.Market Analytics III-25Table 33: European Recent Past, Current and Future Analysisfor Biocompatible Materials by Geographic Region - France,Germany, Italy, UK, and Rest of Europe Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2013 through 2020 (includes corresponding Graph/Chart) III-25Table 34: European Historic Review for BiocompatibleMaterials by Geographic Region - France, Germany, Italy, UK,and Rest of Europe Markets Independently Analyzed withAnnual Sales Figures in US$ Million for Years 2006 through2012 (includes corresponding Graph/Chart) III-26Table 35: European 15-Year Perspective for BiocompatibleMaterials by Geographic Region - Percentage Breakdown ofDollar Sales for France, Germany, Italy, UK, and Rest ofEurope Markets for Years 2006, 2014 and 2020 (includescorresponding Graph/Chart) III-27
Table 36: European Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-28Table 37: European Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-29Table 38: European 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-30
4a. FRANCE III-31Market Analysis III-31Table 39: French Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-31Table 40: French Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-32Table 41: French 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-33
4b. GERMANY III-34A.Market Analysis III-34Current and Future Analysis III-34Evonik Industries AG - A Key Player III-34B.Market Analytics III-35Table 42: German Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-35Table 43: German Historic Review for Biocompatible Materialsby Type - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-36Table 44: German 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-37
4c. ITALY III-38Market Analysis III-38Table 45: Italian Recent Past, Current and Future Analysisfor Biocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-38Table 46: Italian Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-39Table 47: Italian15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-40
4d. THE UNITED KINGDOM III-41A.Market Analysis III-41Current and Future Analysis III-41Implants Product Innovations are focused on Biomaterials III-41Recent Industry Activity III-41Select Players III-41B.Market Analytics III-43Table 48: UK Recent Past, Current and Future Analysis forBiocompatible Materials by Type - Polymeric Materials,Metallic Materials, Natural Materials and Other MaterialsMarkets Independently Analyzed with Annual Sales Figures inUS$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-43Table 49: UK Historic Review for Biocompatible Materials byType - Polymeric Materials, Metallic Materials, NaturalMaterials and Other Materials Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2006through 2012 (includes corresponding Graph/Chart) III-44Table 50: UK 15-Year Perspective for Biocompatible Materialsby Type - Percentage Breakdown of Dollar Sales for PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets for Years 2006, 2014 and 2020 (includescorresponding Graph/Chart) III-45
4e. REST OF EUROPE III-46A.Market Analysis III-46Current and Future Analysis III-46Recent Industry Activity III-46Select Players III-46B.Market Analytics III-49Table 51: Rest of Europe Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-49Table 52: Rest of Europe Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-50Table 53: Rest of Europe 15-Year Perspective forBiocompatible Materials by Type - Percentage Breakdown ofDollar Sales for Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets for Years2006, 2014 and 2020 (includes corresponding Graph/Chart) III-51
5. ASIA-PACIFIC III-52A.Market Analysis III-52Current and Future Analysis III-52Dental Bone Graft Substitutes and Biomaterials Market - AnOverview III-52Table 54: Over 65 Years Individuals as % of TotalPopulation in Select Asian Countries (2012) (includescorresponding Graph/Chart) III-52Focus on Select Regions III-53China III-53Biomaterials Market Overview III-53The Largest Biomaterial Research Country III-53Orthopedic Biomaterials Market III-53India III-53Orthopedic Biomaterials Market III-53Rise in Medical Tourism Drives Biomaterials Market III-54Attractive Market for Prosthetic Heart Valves DeviceManufacturers III-54B.Market Analytics III-55Table 55: Asia-Pacific Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-55Table 56: Asia-Pacific Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-56Table 57: Asia-Pacific 15-Year Perspective for BiocompatibleMaterials by Type - Percentage Breakdown of Dollar Sales forPolymeric Materials, Metallic Materials, Natural Materialsand Other Materials Markets for Years 2006, 2014 and 2020(includes corresponding Graph/Chart) III-57
6. REST OF WORLD III-58A.Market Analysis III-58Current and Future Analysis III-58Brazilian Biomaterial Market - Overview III-58B.Market Analytics III-59Table 58: Rest of World Recent Past, Current and FutureAnalysis for Biocompatible Materials by Type - PolymericMaterials, Metallic Materials, Natural Materials and OtherMaterials Markets Independently Analyzed with Annual SalesFigures in US$ Million for Years 2013 through 2020 (includescorresponding Graph/Chart) III-59Table 59: Rest of World Historic Review for BiocompatibleMaterials by Type - Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years2006 through 2012 (includes corresponding Graph/Chart) III-60Table 60: Rest of World 15-Year Perspective forBiocompatible Materials by Type - Percentage Breakdown ofDollar Sales for Polymeric Materials, Metallic Materials,Natural Materials and Other Materials Markets for Years2006, 2014 and 2020 (includes corresponding Graph/Chart) III-61
IV. COMPETITIVE LANDSCAPETotal Companies Profiled: 59 (including Divisions/Subsidiaries - 64)The United States (41)Japan (2)Europe (19)- France (1)- Germany (2)- The United Kingdom (5)- Rest of Europe (11)Asia-Pacific (Excluding Japan) (1)Middle East (1)
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