WALTHAM, Mass., Feb. 1 Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, for the second-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer, a targeted treatment that increases the median progression-free survival relative to a regimen of GlaxoSmithKline/Nippon Kayaku's Tykerb/Tyverb and Roche/Chugai's Xeloda would earn similar patient share in the U.S. and Europe. Surveyed U.S. oncologists would prescribe such a therapy to 50 percent of their second-line HER2-positive metastatic breast cancer patients. Similarly, in Europe, such an agent would earn 40 percent patient share, according to surveyed European oncologists.
"While a drug's effect on overall survival and progression-free survival are the attributes that most influence surveyed oncologists' prescribing decisions for the second-line treatment of HER2-positive metastatic breast cancer, surveyed oncologists have realistic expectations for new therapies on these measures. As the HER2-positive segment of the breast cancer market is set to become more crowded with new agents such as Roche's trastuzumab-DM1 (T-DM1), Pfizer's neratinib and Roche/Chugai's pertuzumab, all forecast to launch before 2018, uptake will rely on providing meaningful improvements in overall survival and progression-free survival," stated Decision Resources Analyst Regina Jammen, M.S.
The new report entitled Metastatic HER2-Positive Breast Cancer: KOLs and Surveyed Oncologists Maintain Strong Enthusiasm for T-DM1 as an Important Second-Line Treatment for HER2-Positive Breast Cancer also finds that T-DM1 earns Decision Resources' proprietary clinical gold standard status for the second-line treatment of HER2-positive metastatic breast cancer in 2013 and 2018, following its approval in 2011 for third-line treatment of HER2-positive metastatic breast cancer (2013 approval for second-line treatment). T-DM1 has competitive advantages in efficacy and safety relative to a regimen of Tykerb/Tyverb and Xeloda.
About the Report
Metastatic HER2-Positive Breast Cancer: KOLs and Surveyed Oncologists Maintain Strong Enthusiasm for T-DM1 as an Important Second-Line Treatment for HER2-Positive Breast Cancer is a DecisionBase 2010 report. DecisionBase 2010 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.
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