First Cognitive Training to Demonstrate Generalization on Standarized Assessments of Memory

Friday, September 5, 2008 General News J E 4
SAN FRANCISCO, Sept. 4 Preliminary results from the IMPACTstudy are being presented today at the International College of GeriatricPsychoneurpharmacology's 8th Annual Scientific Meeting in Randwick, New SouthWales, Australia. The purpose of the IMPACT ("Improvement in Memory withPlasticity-based Adaptive Cognitive Training") study was to evaluate whetherimprovements from specialized cognitive training extend to standardized,untrained measures of memory performance and to self-reported everydaycognition.

Henry Mahncke, PhD and Vice President of Research and Outcomes for SanFrancisco-based Posit Science is presenting the data. The IMPACT trialcompares the benefits of a plasticity-based cognitive training programdeveloped by Posit Science (the Brain Fitness Program) to a computer-basedlearning control matched for computer usage and training intensity. It waschosen to represent current clinical recommendations regarding "stayingcognitively active." The IMPACT study is the first large-scale randomizedcontrolled trial of a non-invasive, computer-based cognitive intervention foraging adults that is available for widespread, individual use. In addition tousing standardized neuropsychological tests to assess training-related changesin memory, the IMPACT study measured the improvements in cognitive abilitiesdirectly reported by study participants themselves.

Using an intensive series of adaptive computerized exercises, the BrainFitness Program is designed to target the speed and accuracy of auditory andlanguage processes, and neuromodulatory systems associated with learning andmemory. Predefined endpoints distinct in design and content from trainingexercises included standardized neuropsychological assessments of memory andparticipant-reported outcome (PRO) assessments measuring perceptions ofeveryday cognition.

After 10 weeks of training, significant group by time interactionsfavoring the experimental group (the Brain Fitness Program) were seen on theprimary endpoint measure (RBANS Auditory Memory) and multiple within-modalitybut not cross-modality secondary endpoint measures. PRO measures of everydaycognitive function were significant on pre-post and post-only assessments.

Principal Investigators in this prospective, randomized, controlled trialwere Glenn Smith, PhD at Mayo Clinic and Elizabeth Zelinski, PhD at theUniversity of Southern California. The study involved 524 healthy adults overthe age of 65.

About Posit Science

Posit Science is the leading provider of clinically validated brainfitness products and services. The company works with more than 50 scientistsfrom prestigious universities to design and test its computer-based programs.More than 30 published studies show that the company's patented technologiessignificantly increase the brain's processing speed, improve memory, andenhance the quality of everyday life. Posit Science has received numerousgrants, awards and accolades from organizations including the NationalInstitutes of Health (NIH), the American Society for Aging (ASA), and CNBC.For more information visit or call 1-866-599-6463.

SOURCE Posit Science


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