Expert Update on Cancer Stem Cells and Cancer Stem Cell Inhibitors in Gastrointestinal Cancers
LONDON, June 23, 2016 /PRNewswire/ --
Joleen M Hubbard, Axel Grothey, Oncology & Hematology Review, 2016;12(1):41-6 http://doi.org/10.17925/OHR.2016.12.01.41
Recently in Oncology & Hematology Review, the peer-reviewed journal from touchONCOLOGY, Joleen M Hubbard and Axel Grothey, introduce cancer stem cells (CSCs) as a subpopulation of phenotypically distinct cancer cells that may play an important role in tumor pathogenesis. The gastrointestinal (GI) system provides a good example for investigation of the role of CSCs in tumor proliferation; GI CSCs are suitable for study due to their abundance, proliferative potential, and consistent structural arrangement that is maintained under tightly controlled signaling pathways. GI stem cells have a long lifespan and this, combined with their rapid turnover, may predispose them to forming CSCs. Alternative possible sources of GI CSCs include differentiated intestinal cells, bone marrow, and cancer cells. Therapies that specifically target CSCs present an exciting opportunity to treat patients with cancer. Enhanced understanding of CSC markers, such as CD133, CD44, and epithelial cell adhesion molecule (EpCAM), may facilitate development of therapies that target them. Among the stemness pathways that have been targeted are Wnt/?-catenin, STAT, Notch, and Nanog.
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The full peer-reviewed, open-access article is available here:
Joleen M Hubbard receives research support from Boston Biomedical. Axel Grothey has nothing to disclose in relation to this article.
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