European Society for Medical Oncology (ESMO) - White Blood Cell Count Predicts Response to Lung Cancer Immunotherapy

Friday, May 5, 2017 General News
Email Print This Page Comment
Font : A-A+

GENEVA, May 5, 2017 /PRNewswire/ --

White blood cell counts can predict whether or not lung cancer patients will

benefit from immunotherapy, according to research presented at the European Lung Cancer Conference (ELCC).

"Immune checkpoint inhibitors such as nivolumab and pembrolizumab significantly improve overall survival in some - but not all - patients

with non-small cell lung cancer (NSCLC)," said Dr Marcello Tiseo, Coordinator of DMT Thoracic Oncology, University Hospital of Parma, Italy. "Researchers are looking for a predictive biomarker to select patients that will benefit from this treatment to avoid unnecessary toxicity and a waste of resources in patients who will not respond."

He continued: "PD-L1 expression in a biopsy of tumour tissue is now used to select patients but it is not completely accurate, possibly because it does not reflect the evolving immune response. Biomarkers in the blood are easier to obtain and may be better indicators of immune response."

This study assessed the ability of white blood cell counts to predict whether lung cancer patients responded to treatment with nivolumab. The study included 54 patients with NSCLC who received nivolumab at a dose of 3 mg/kg every 14 days.

The researchers found that white blood cell counts at baseline and during therapy did predict whether lung cancer patients would respond to nivolumab treatment. A greater number and concentration of natural killer cells at baseline was associated with response to nivolumab, as was an increase in the number of natural killer cells during treatment.

Full story: http://esmo.org/Conferences/ELCC-2017-Lung-Cancer/News-Press-Releases/White-Blood-Cell-Count-Predicts-Response-to-Lung-Cancer-Immunotherapy

ESMO is the leading professional organisation for medical oncology, with over 15,000 members representing oncology professionals from over 130 countries worldwide.

ELCC Press Office media@esmo.org +41-(0)-91-973-19-07

SOURCE European Society for Medical Oncology (ESMO)



Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Press Release Category

Press Release Archive

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook