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Data Published in Leading Respiratory Journal Reinforce Importance of Small Airways In Asthma Management

Tuesday, December 8, 2009 Respiratory Disease News J E 4
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HORSHAM, Pa., Dec. 7 Teva Respiratory, a division of Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA), today announced the publication of four articles in a special supplement of the December issue of the Journal of Allergy and Clinical Immunology (JACI), providing a comprehensive scientific review of the emerging role of the small airways in the understanding and treatment of asthma. This represents the first time leading researchers from various institutions in the U.S. and Canada have organized information surrounding the small airways in asthma to set a benchmark for additional discussion and future research in this area.

Although increasing evidence supports the importance of small airways in the diagnosis and treatment of asthma, focused areas of discussion and critical review of this topic have been lacking. Additionally, while there has been significant progress in the diagnosis of asthma, including prevention, education and treatment, asthma remains a major public health concern as millions of people still experience flare ups and miss school and work days as a result every year.

"It is important for both patients and physicians to have a clear understanding of the role of the small airways in the pathology of asthma," said study author Richard J. Martin, MD, Chairman, Department of Medicine, National Jewish Health in Denver, CO. "Poorly controlled inflammation in the small airways may exacerbate asthma symptoms, such as coughing and shortness of breath, which may lead to an asthma attack or need to seek emergency care. Physicians should consider an inhaled corticosteroid controller medication with a small particle size that delivers medication to both the large and small airways."

The below chart highlights the four articles included in the supplement that were developed following the April 2009 symposium at which leading asthma specialists discussed various aspects surrounding the importance of small airways in asthma management*:

National guidelines recommend inhaled corticosteroids (ICSs) as first-line therapy to achieve asthma control; however, most of these medications do not reach and treat the small airways due to their large particle size, therefore, small airway inflammation remains largely uncontrolled. There are treatments available with extra-fine particle size, such as QVARŪ, which allows asthma control to be delivered deep in the lung, due to more effective penetration throughout the large and small airways. Patients should talk to their healthcare provider to learn more about available treatment options that reach and treat both large and small airways.

* The symposium was funded through an unrestricted grant by Teva Respiratory, LLC.

About Asthma

Asthma is a chronic (long-term), treatable lung disease that causes narrowing of the large and small airways, making breathing difficult at times. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath and coughing that often occurs at night or early in the morning. Without appropriate treatment, asthma symptoms may become more severe and result in an asthma attack, which can lead to hospitalization and even death.

Asthma affects people of all ages, but it most often starts in childhood. In the U.S., more than 22 million people are known to have asthma, including more than 6 million children. Each year in the U.S., asthma causes approximately 500,000 hospitalizations, 134 million days of restricted activity and 4,000 deaths.

About QVARŪ

QVARŪ (beclomethasone dipropionate HFA) Inhalation Aerosol is indicated in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age or older. QVARŪ is also indicated for asthma patients who require systemic corticosteroid administration, where adding QVARŪ may reduce or eliminate the need for systemic corticosteroids.

Important Safety Information

QVARŪ is not a bronchodilator and is not indicated for relief of acute bronchospasm. Common side effects associated with the use of QVARŪ and placebo in clinical trials includes, but is not limited to, headache (12% and 9%, respectively) and pharyngitis (8% and 4%, respectively). Caution: Adrenal insufficiency may occur when transferring patients from systemic steroids (see WARNINGS, Prescribing Information). A reduction in growth velocity in growing children and teenagers may occur as a result of inadequate control of chronic diseases such as asthma or from use of corticosteroids for treatment.

For full Prescribing Information please click here: http://www.qvar.com/Document/PrescribingInformation.pdf.

About Teva Respiratory

Teva Respiratory is the U.S.-based respiratory division of Teva Pharmaceutical Industries Ltd. Teva Pharmaceutical Industries Ltd., headquartered in Israel, is among the top 20 pharmaceutical companies in the world and is the leading generic pharmaceutical company. The company develops, manufactures and markets generic and innovative human pharmaceuticals and active pharmaceutical ingredients. Over 80 percent of Teva's sales are in North America and Europe.

Article Title Key Highlights------------- --------------* The Importance and Features * The small airways play an of the Distal Airways in Children important role in the and Adults pathology of asthma (E. W. Gelfand and M. Kraft) * Inflammation of small airways may exacerbate asthma, contribute to an accelerated decline in lung function and promote airway remodeling* Anatomy, Pathology, and Physiology * Airway inflammation and of the Tracheobronchial Tree: Emphasis remodeling that on the Distal Airways characterize asthma occur (D. M. Hyde, Q. Hamid and C. G. Irvin) in the small airways * Small airways are an important target for asthma therapy* Particle Size of Inhaled Corticosteroids: * HFA solution metered-dose Does it Matter? inhalers, such as QVAR(R), (C. Leach, G. L. Colice and A. Luskin) produce small particles that are able to reach and treat the large and small airways * Most inhaled medications do not reach the small airways where many of the pathological changes in asthma may occur * Reformulated QVAR(R) does not have greater systemic effects* Imaging of the Distal Airways * High-resolution CT imaging (D. Tashkin and E. E. de Lange) can assess small airway role in asthma * Traditional imaging methods cannot measure small airway function

SOURCE Teva Respiratory, a division of Teva Pharmaceutical Industries, Ltd.
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