Correction: Shire plc: Third Quarter 2007 results date notification November 1, 2007

Thursday, October 18, 2007 General News J E 4
BASINGSTOKE, England, Oct. 17 Below is updatedtext of Shire plc's conference call notification. Please note U.S. releasetimes and conference call times have been updated from an earlier release.

Shire PLC (LSE: SHP, Nasdaq: SHPGY, TSX: SHQ) the global specialtybiopharmaceutical company, will announce third quarter 2007 earnings onThursday 1 November 2007.

Matthew Emmens, Chief Executive Officer and Angus Russell, ChiefFinancial Officer will host the live conference call for investors at 14:30GMT/10:30 ET.

Please RSVP (T: +44(0)1256-894-160) for this conferencecall.

A replay of the presentation will be available for two weeks by phone andby webcast for one year. Details are as follows:

Shire PLC

Shire's strategic goal is to become the leading specialtybiopharmaceutical company that focuses on meeting the needs of the specialistphysician. Shire focuses its business on attention deficit and hyperactivitydisorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) andrenal diseases. The structure is sufficiently flexible to allow Shire totarget new therapeutic areas to the extent opportunities arise throughacquisitions. Shire's in-licensing, merger and acquisition efforts are focusedon products in niche markets with strong intellectual property protectioneither in the US or Europe. Shire believes that a carefully selected portfolioof products with strategically aligned and relatively small-scale sales forceswill deliver strong results.

For further information on Shire, please visit the Company's website: press release will be issued at: 12:00 GMT / 08:00 ET Investor meeting and conference call time: 14:30 GMT / 10:30 ET Live conference call for investors:



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