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PRC is the most frequently occurring cancer among males in developedcountries and accounts for nine percent of cancer deaths in men, second onlyto lung cancers. PRC is frequently asymptomatic in the early stages, and laterstage diagnosis greatly reduces the efficacy of available therapeutic methods.
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This project sets a vivid example of international cooperation betweenleading Russian and U.S. research centers in medical science research aimed atlife threatening diseases. CDRI and its collaborators will deploy post-genometechnologies including rational drug design and medicinal chemistry, chemicalgenomics and systems biology to support efficient preclinical discovery anddevelopment programs. The American partners from the Oak Ridge NationalLaboratory (ORNL, DOE) will provide a knowledge base system for chemical andbiological information, using Modular Chemical Descriptor Language technology.Experts from other Russian leading academic research institutions and the NCIwill be engaged in the project.
"ChemDiv and CDRI established a long track record of success in leaddiscovery, with specific expertise in oncology pathway chemistry and biology,"said Dmitry Kravchenko, General Director of CDRI. "This opportunity allows usto expand our collaboration with the leading experts in oncology and rationaldrug design in an especially meaningful context -- targeting a major unmetneed for new approached to the prevention and treatment for prostate cancer inUnited States, Russia, and world wide."
The initial two-year partnership has received financial commitments inexcess of US$1,000,000. CDRI and DOE will have joint rights to commercializeproducts in most of the world, whereas CDRI will have exclusive commercialrights for markets in Russia and certain other countries.
About The Global Initiatives for Proliferation Prevention Program of theU.S. Department of Energy (GIPP/DOE): The mission of The Global Initiativesfor Proliferation Prevention program encourages and supports cooperativecivilian research between US research teams and researchers from the countriesof the former USSR, utilizing their extensive hi-tech and scientificexperience. The goals of GIPP-sponsored joint projects are to promoteidentification and utilization of new scientific and technical resources, andto increase the investment appeal and commercial potential of technologiesdeveloped in scientific research institutes of the former Soviet Union.
http://www.nnsa.doe.gov
About CDRI: The Chemical Diversity Research Institute, housed in dedicatedworld-class research facilities in Moscow, is a leading Russian commercialbiotech specialized in advanced combinatorial, medicinal and computationalchemistry; and high-throughput screening for early drug discovery.
http://www.iihr.ru
About ChemDiv: ChemDiv Inc. (Chemical Diversity) is a globalchemistry-driven contract research organization focused on identifying anddelivering pre-clinical opportunities and services for life science partners,merging industrial and academic efforts to bring new approaches to thetreatment of life-threatening diseases.
http://www.chemdiv.com
About Blokhin Russian Oncology Center (RONC): The Russian Oncology Centeris the leading oncology research and clinical institution specialized indiagnostics and development of anticancer therapies. Th
