Advertisement
The study was a randomized, double-blind, parallel group, placebo-controlled study, in which half of the subjects received the topical diclofenac patch and the other half received a placebo patch. Individuals were treated for seven days and assessed their pain relief for reduction in pain at three and seven days, using an 11-point numerical rating scale (NRS) where 0 equals no pain and 10 equals worst pain possible.
Advertisement
"People need safer, more effective and convenient treatments for their pain," commented Paul Sekhri, President and CEO of Cerimon Pharmaceuticals. "Our diclofenac patch is designed to offer once-daily, site-specific pain relief without the systemic side effects associated with oral NSAIDs, and with superior skin penetration, optimal adhesiveness, and better feel and flexibility than other topical pain patches currently available or in development. We are very excited about the results of our SUPPORT study and look forward to further progress in this program."
Based on the results of the SUPPORT study, Cerimon intends to initiate its Phase III program of the diclofenac patch by early 2009.
Acute Pain
Musculoskeletal pain is pain that affects the muscles, ligaments, tendons and bones. Acute musculoskeletal injuries are common and can occur during sports activities, exercise or other physical activities. Acute musculoskeletal injuries generally require rapid treatment, which often includes the administration of anti-inflammatory drugs. Optimal topical treatment should relieve acute pain and reduce swelling in the injured area to restore normal movement. In addition, it should be safe and easy to administer.
Pain Market
Pain represents a large and dynamic market in the United States. Oral formulations of non-steroidal anti-inflammatory drugs (NSAID) currently are marketed worldwide for the treatment of inflammation and pain, including pain due to musculoskeletal injuries, signs and symptoms of osteoarthritis and rheumatoid arthritis, menstrual cramps, headache and other minor aches and pains. While traditional oral NSAIDs are effective, they can cause serious gastrointestinal and cardiovascular adverse events. Further, the withdrawal of some COX-2 inhibitors, a class of NSAIDs, has removed a major therapeutic option for patients with multiple moderate and severe forms of pain, resulting in a significant market opportunity. These developments have created an important need for a localized pain product with a strong safety profile.
About Cerimon Pharmaceuticals
Cerimon Pharmaceuticals, Inc., is a biopharmaceutical company dedicated to developing and commercializing therapeutic products for autoimmune diseases, inflammation and pain. Cerimon believes these new treatment options will enable physicians specialized in treating these condi