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Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems

Wednesday, April 2, 2008 General News
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SAN DIEGO, April 1, 2008 Cardium Therapeutics(Amex: CXM) and its operating unit InnerCool Therapies announced today thatInnerCool has entered into a European commercialization agreement with EuromedMedizinisch GmbH (Euromed), a leading distributor of cardiology medicalproducts. Under the terms of the agreement, Euromed will have exclusivemarketing, sales and distribution rights in Austria, Germany and Switzerlandfor InnerCool's portfolio of temperature modulation systems. This agreementcovers InnerCool's CoolBlue(TM), a nurse-friendly and cost-effective surfacecooling temperature modulation system, which was launched in the U.S. marketduring the fourth quarter 2007, as well as InnerCool's, premium-priced,high-performance RapidBlue(TM) endovascular cooling system, which is expectedto be launched in the U.S. market in the second quarter 2008. Using Euromed'smarketing and sales force, sales of CoolBlue consoles and disposables areexpected to begin in Europe this quarter, and sales of RapidBlue consoles anddisposables are expected to begin next quarter.
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"We are pleased to have this distribution agreement with Euromed. Theyhave a knowledgeable medical sales force with clinical support in our targetedmarkets, as well as extensive experience in selling temperature modulationproducts," stated Christopher J. Reinhard, Chairman and Chief ExecutiveOfficer of Cardium Therapeutics and InnerCool Therapies. "This new Europeanpartnership, along with our recent distribution agreement for Australia andNew Zealand, are consistent with our strategy of accelerating the growth ofInnerCool's temperature modulation business in an efficient and cost-effectivemanner by establishing relationships with existing specialized internationalsales organizations."
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"We are well positioned to successfully initiate marketing and selling theCoolBlue system in Austria, Switzerland and Germany," stated Reinhold Eder,Chief Executive Officer of Euromed, "and we look forward to expanding ourdistribution activities to include InnerCool's next-generation RapidBluesystem when it becomes available later in the year. We believe InnerCool isthe only company positioned to offer a comprehensive portfolio ofbest-in-class temperature modulation solutions for physicians and healthcareproviders in this rapidly expanding therapeutic area."

InnerCool's Surface and Endovascular Temperature Modulation Systems

InnerCool's new CoolBlue(TM) surface temperature modulation system, whichincludes a console and a disposable CoolBlue vest with upper thigh pads, isdesigned to provide a tool for use in less acute patients or in clinicalsettings best suited to prolonged temperature management. InnerCool'sCoolBlue vest and thigh pads wrap the body without requiring any adhesives tostick to the skin and produce cooling rates of around 1 degree C per hour,i.e. similar to those of currently-marketed surface cooling systems andendovascular systems using inflatable balloon-based catheters. InnerCool'sCoolBlue external or surface-based temperature modulation system is designedto cool or warm patients from outside of their bodies and is intended for usein less acute settings such as in-hospital fever management.

InnerCool's next-generation RapidBlue(TM) system for high-performanceendovascular temperature modulation is expected to receive FDA clearance inthe second quarter 2008, and to initially have the same clearance as itscurrent Celsius Control(TM) System. The RapidBlue system includes aprogrammable console with an enhanced user interface and a catheter designedto quickly modulate patient temperature in association with surgery or othermedical procedures. The RapidBlue system powers InnerCool's Accutrol(TM)catheter, which has a flexible metallic temperature control element and abuilt-in temperature feedback sensor to prov
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