HOPKINTON, Mass., July 15 Caliper Life Sciences,Inc. (Nasdaq: CALP) today introduced two microfluidics-based separationsproducts, the LabChip(R) GX and LabChip GXII benchtop systems, for fast,automated, 1-D electrophoretic separations of protein, DNA, and RNA samples.The LabChip GX represents a low price entry system targeted at genomicsapplications, while the GXII combines both genomics and protein researchapplications. The LabChip GX series of instruments will be marketed by Caliperand is designed to provide scientists novel benefits including extended walkaway time, higher throughput and economical plate processing ability. Caliperalso provides solutions to scientists with lower throughput needs through itscollaborations with Agilent and Bio-Rad.
Both systems combine Caliper's highly reproducible assay technology withadvanced data analysis and visualization software. With 96-well and 384-wellplate compatibility and the ability to select single wells at any location ina plate, the LabChip GX and GXII systems provide researchers with unmatchedthroughput, flexibility, and performance. Leveraging Caliper's patentedmicrofluidics technology, users are able to thoroughly analyze samples inseconds instead of minutes, eliminating throughput bottlenecks and improvingefficiency. The advanced data management software suite included with eachsystem allows users to visualize results via an electropherogram or virtualgel view. Additionally it provides data in tabular form, which can then beanalyzed or easily exported into a spreadsheet format.
"With applications ranging from protein therapeutics research to geneexpression analysis to genotyping of transgenic mice, the LabChip GX and GXIIrepresent an integral component of Caliper Life Sciences' overall strategy ofdeveloping products that bridge the in vitro - in vivo translational gap,"said Rick Bunch, Microfluidics Product Manager, Caliper Life Sciences. "TheLabChip GX and GXII provide high quality, accurate, and reproducible data thatenable researchers to accelerate their discovery efforts, while saving timeand money."
The new LabChip GX instrument has been designed expressly for the needs ofgenomics researchers for the analysis of RNA integrity for better RT-PCR andmicroarray gene expression data, DNA fragment analysis for sequencingapplications and genotyping transgenic mice, and numerous other applicationsthat require accurate size, concentration, or purity analysis of nucleic acidsamples. A unique feature of the LabChip GX is the ability to analyze anysingle sample, or a subset of samples in a microtiter plate using an intuitiveGUI interface. This feature enables researchers to assess RNA integrity byrandomly sampling a plate or conduct "hit picking" experiments on samples ofparticular interest.
The LabChip GXII system, which is a complete functional replacement of theLabChip 90, provides consistent and precise analysis of both protein andnucleic acid samples. The LabChip 90 has been widely adopted by researchersdeveloping antibody-based therapeutics and is ideally suited for quantifyingsize, titer, purity, and fragmentation. This automated separations platformalso enables scientists to explore the effect of multiple variables inparallel -- a process which is prohibitively expensive and time-consumingusing manual methods. As a direct consequence, robust methods for proteinexpression can be established that accelerate high throughput screening,crystallography, and analytical analyses that require large amounts ofprotein.
Caliper offers a broad portfolio of microfluidics chips and DNA, RNA, andprotein assay kits to use with the GX and GXII systems. For additionalinformation or to order the LabChip GX or GXII, please visit:http://www.caliperls.com/products/labchip-systems/.
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