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CEL-SCI Corporation is developing products that empower immune defenses.Its lead product is Multikine(R). In Phase II clinical trials Multikine wasshown to be safe and well-tolerated, and to improve the patients' overallsurvival by 33% at a median of three and a half years following surgery. TheU.S. Food and Drug Administration (FDA) gave the go-ahead for a Phase IIIclinical trial with Multikine in January 2007 and granted orphan drug statusto Multikine in the neoadjuvant therapy of squamous cell carcinoma (cancer) ofthe head and neck in May 2007.
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Multikine, a patented defined mixture of naturally derived cytokines, isthe first immunotherapeutic agent in a new class of drugs called "ImmuneSIMULATORS". Immune SIMULATORS simulate the way our natural immune systemacts in defending us against cancer. As opposed to other immunotherapieswhich are designed to target a single or limited number of specific antigensor molecules, Immune SIMULATORS are multi-targeted; they simultaneously causea direct and targeted killing of the specific tumor cells and they activatethe immune system to produce a stronger anti-tumor attack on multiple fronts.
Multikine is also the first immunotherapeutic agent being developed as afirst-line standard of care treatment for cancer. It is administered prior toany other cancer therapy because that is the period when the anti-tumor immuneresponse can still be fully activated. Once the patient has advanced disease,or had surgery or has received radiation and/or chemotherapy, the immunesystem is severely weakened and is less able to mount an effective anti-tumorimmune response. Other immunotherapies are administered after the patient hasreceived chemotherapy and/or radiation therapy, which can limit theireffectiveness.
The Company has operations in Vienna, Virginia and Baltimore, Maryland.CEL-SCI's other products, which are currently in pre-clinical stage, haveshown protection against a number of diseases in animal tests and are beingtested against diseases associated with bio-defense and avian flu.
SOURCE CEL-SCI Corporation
