COLUMBUS, Ohio, Aug. 24 /PRNewswire/ -- Today, leukemia patients who have struggled with cancer therapy resistance and intolerancewill now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a rapid increase in journal and patent publications following the discovery of Gleevec, as reported by Chemical Abstracts Service (CAS), the
Since President Clinton announced that the draft sequence of the human genome was completed in 2000, research about specific types of cancers grew exponentially. Fifty years of cancer and Chronic Myelogenous Leukemia (CML) drug treatments are examined in the CAS Chemistry Research Report: Human Genome Discoveries Spur Growth of Cancer Treatments. CAS researchers confirmed that Gleevec succeeded as a first-generation drug that targeted CML, as originally reported by Novartis and Oregon Health and Science researchers. Second- and third-generation CML-targeted drugs benefited from Gleevec's patent success and continued to propel the growth of CML research and patent publications.
Other important findings from the CAS report include:
"The results of the analysis outlined in the CAS Chemistry Research Report further validate that we are on the right course," said Dr. Brian Druker, Director, Oregon Health & Science University Knight Cancer Institute. "The accelerated growth in CML-related publications following Gleevec provides yet more evidence that the targeting approach opened up new paths of exploration for the medical and scientific communities. Based on this success we are now optimistic that all cancers could be controlled with drugs like Gleevec."
Chemical Abstracts Service (CAS), a division of the American Chemical Society, is the world's authority for chemical information. Our databases are curated and quality-controlled by CAS scientists, and recognized by chemical and pharmaceutical companies, universities, government organizations, and patent offices around the world as comprehensive and authorative. By combining these databases with advanced search and analysis technologies (SciFinder®, STN®, and Science IP® products and services), CAS delivers the most current, complete, and cross-linked secure digital information environment for scientific discovery.
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