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Amicus Therapeutics Announces Plans to Present Phase 1 Data for AT2220 for Pompe Disease

Wednesday, September 19, 2007 General News J E 4
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CRANBURY, N.J., Sept. 18 Amicus Therapeutics(Nasdaq: FOLD) today announced that it plans to present the results of Phase 1studies of AT2220 (1-deoxynojirimycin HCl) for Pompe Disease at the AmericanSociety of Human Genetics (ASHG) Annual Meeting on October 23-27 in San Diego,CA. This plan was announced by John Crowley, President and Chief ExecutiveOfficer, at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007Conference in London, United Kingdom.

About Amicus Therapeutics

Amicus Therapeutics is a biopharmaceutical company developing novel, oraltherapeutics known as pharmacological chaperones for the treatment of a rangeof human genetic diseases. Pharmacological chaperone technology involves theuse of small molecules that selectively bind to and stabilize proteins incells, leading to improved protein folding and trafficking, and increasedactivity. Amicus is initially targeting lysosomal storage disorders, which aresevere, chronic genetic diseases with unmet medical needs. Amicus has twoproduct candidates in Phase II clinical trials, Amigal(TM) for the treatmentof Fabry disease and Plicera(TM) for the treatment of Gaucher disease. TheCompany is also conducting Phase I clinical trials of AT2220 for the treatmentof Pompe disease.

Forward-Looking Statements

Amicus cautions you that statements included in this press release thatare not a description of historical facts are "forward-looking statements"within the meaning of Section 21E of the Private Securities Litigation ReformAct of 1995. Words such as, but not limited to, "look forward to," "believe,""expect," "anticipate," "estimate," "intend," "plan," "targets," "likely,""will," "would," "should," and "could," and similar expressions or wordsidentify forward-looking statements. Such forward-looking statements are basedupon current expectations that involve risks, changes in circumstances,assumptions and uncertainties. The inclusion of forward-looking statementsshould not be regarded as a representation by Amicus that any of its planswill be achieved. Any or all of the forward-looking statements in this pressrelease may turn out to be wrong. They can be affected by inaccurateassumptions Amicus might make or by known or unknown risks and uncertainties.For example, with respect to statements regarding the potential progress andresults of clinical trials, actual results may differ materially from thoseset forth in this release due to the risks and uncertainties inherent in thebusiness of Amicus, including, without limitation: the respective Phase IIclinical trials for Amigal(TM) and Plicera(TM), and the Phase I clinical trialfor AT2220 may not proceed in the timeframes or in the manner Amicus expectsor at all. Further, the results of earlier clinical trials may not bepredictive of future results; Amicus and its licensors may not be able toobtain, maintain and successfully enforce adequate patent and otherintellectual property protection of its product candidates; and other risksdetailed in the public filings of Amicus with the Securities and ExchangeCommission. You are cautioned not to place undue reliance on theseforward-looking statements, which speak only as of the date hereof. Allforward-looking statements are qualified in their entirety by this cautionarystatement and Amicus undertakes no obligation to revise or update this newsrelease to reflect events or circumstances after the date hereof. This cautionis made under the safe harbor provisions of Section 21E of the PrivateSecurities Litigation Reform Act of 1995.

SOURCE Amicus Therapeutics
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