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American Heart Association Late-Breaking Clinical Trial Report: One-Year Mortality Similar In Patients Undergoing Angioplasty for Acute Heart Attacks at Hospitals With and Without Cardiac Surgery Capability

Tuesday, November 17, 2009 General News J E 4
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Study highlights:

- Patients undergoing angioplasty in the midst of a heart attack have similar death rates at one-year follow-up whether the procedure was done at hospitals with or without on-site cardiac surgery.

- Recurrent heart attack and additional angioplasty was more common in patients having angioplasty at hospitals without on-site surgery.

ORLANDO, Fla., Nov. 16 /PRNewswire-USNewswire/ -- One-year mortality is similar at hospitals with or without on-site cardiac surgery for patients undergoing primary percutaneous coronary intervention (PCI) to treat an on-going heart attack, researchers reported in a late-breaking clinical registry study presentation at the American Heart Association's Scientific Sessions 2009.

In the Outcomes Following Primary Percutaneous Coronary Intervention: A Comparison Between Hospitals With and Without Cardiac Surgery On-Site study, researchers sought to determine whether patients fared better after having primary PCI at hospitals with cardiac surgery on site (SOS) compared to those having PCI at community hospitals without cardiac surgery on site (No SOS).

They found the rate of death at 30 days and one-year follow-up was no different following primary PCI at either type of facility (one year = 9.41 percent with SOS vs. 8.58 percent without SOS).

"Primary PCI, meaning PCI during the acute phase of a heart attack, is the preferred treatment of an ST-elevation myocardial infarction (STEMI), but it is not widely available," said Ather Anis, M.D., lead author of the study. "Performing PCI at community hospitals without cardiac surgery on site could increase the number of STEMI patients with timely access to this lifesaving procedure."

Primary PCI at hospitals without SOS is not routinely done, though many states have approved its use at hospitals that meet certain American College of Cardiology/American Heart Association guidelines for procedure volume.

To increase the number of STEMI patients with timely access to primary PCI, the Massachusetts Department of Health approved a pilot program in 1997 for primary PCI at hospitals without SOS to determine its safety and effectiveness, said Alice K. Jacobs, M.D., senior author of the study and professor of medicine and director of the Cardiac Catheterization Laboratories and Interventional Cardiology at Boston University Medical Center in Massachusetts.

The researchers analyzed 3,018 STEMI patients who underwent primary PCI, including 977 treated at No SOS hospitals, between January 2005 and September 2007, whose data was collected in the Massachusetts Data Analysis Center registry. The No SOS hospitals had the capability of performing cardiac catheterization for diagnostic purposes, but without a cardiothoracic surgery program they would not routinely have done PCI.

The study had four primary endpoints that researchers analyzed separately: all-cause mortality, recurrent heart attack, repeat need for PCI, and reopening of the originally blocked vessel (target vessel revascularization) at 30 days and one year.

As with mortality, researchers found little difference among patients needing a repeat procedure to reopen the originally blocked cardiac vessel.

"However, patients undergoing primary PCI at hospitals without SOS had a slightly higher incidence of recurrent heart attack at 30 days for reasons that are unclear and will require further study," said Anis, a fellow at Boston University Medical Center during the study who is now in practice in Winchester/Northern Virginia.

At one year, the rate of recurrent heart attack was 6.66 percent at hospitals without SOS vs. 5.06 percent (p=0.11) at those with on-site cardiac surgery.

Although target vessel revascularizations were the same between groups, researchers found more revascularizations of other coronary arteries in the No SOS group, which could indicate more staged procedures in patients in the No SOS group with multi-vessel disease.

The goal of primary PCI is to reopen the blockage causing the heart attack as quickly as possible to re-establish blood flow to the heart. This means treatment of other blockages is usually delayed, i.e. staged, until the patient has recovered from the heart attack.

The study was funded through a contract with the Massachusetts Department of Public Health.

Co-authors are: Sharon-Lise T. Normand, Ph.D.; Robert E. Wolf, M.Sc.; Ann Lovett, R.N., M.A.; Laura Mauri, M.D., M.Sc.; and Neal Patel, M.D.

Disclosures: Four of the authors (Anis, Mauri, Patel and Jacobs) perform PCI at hospitals with SOS.

NR09-1163 (SS09/ANIS)

SOURCE American Heart Association
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