PHARMA - Valproic Acid

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Valproic Acid

Valproic acid - Encorate, Epilex, Epival, Valparin, Valtril
Use:

Management of simple and complex absence seizures; mixed seizure types; myoclonic and generalized tonic-clonic (grand mal) seizures; may be effective in partial seizures, infantile spasms, bipolar disorder; prevention of migraine headaches

Pregnancy & Lactation :
Risk Factor - D
Warnings & Precautions:

Hepatic failure resulting in fatalities has occurred in patients; children <2 years of age are at considerable risk; monitor patients closely for appearance of malaise, weakness, facial edema, anorexia, jaundice, and vomiting; may cause severe thrombocytopenia, bleeding; hepatotoxicity has been reported after 3 days to 6 months of therapy;tremors may indicate overdosage; use with caution in patients receiving other anticonvulsants

Contraindication:

Hypersensitivity to valproic acid or derivatives or any component; hepatic dysfunction

Adverse Reactions :

1% to 10%: Endocrine & metabolic: Change in menstrual cycle Gastrointestinal: Abdominal cramps, anorexia, diarrhea, nausea, vomiting, weight gain.
<1%: Drowsiness, ataxia, irritability, confusion, restlessness, hyperactivity, headache, malaise, alopecia, erythema multiforme, hyperammonemia, pancreatitis, thrombocytopenia, prolongation of bleeding time, transient increased liver enzymes, liver failure, tremor, nystagmus, spots before eyes


Interactions :

CYP2C19 enzyme substrate; CYP2C9 and 2D6 enzyme inhibitor, CYP3A3/4 enzyme inhibitor (weak) Decreased effects of phenytoin Decreased effects with carbamazepine, lamotrigine, possibly clonazepam (increased absence seizures have been reported) Increased effects/toxicity of diazepam, CNS depressants, alcohol Increased effects/toxicity with aspirin (increase valproic acid levels)


Over Dose / Poisoning :

Symptoms of overdose include coma, deep sleep, motor restlessness, visual hallucinations Supportive treatment is necessary; naloxone has been used to reverse CNS depressant effects, but may block action of other anticonvulsants


Dosage :

Children and Adults: Oral: Initial: 10-15 mg/kg/day in 1-3 divided doses; increase by 5-10 mg/kg/day at weekly intervals until therapeutic levels are achieved; maintenance: 30-60 mg/kg/day in 2-3 divided doses Children

receiving more than 1 anticonvulsant (ie, polytherapy) may require doses up to 100 mg/kg/day in 3-4 divided doses I.V.:Administer as a 60 minute infusion (< or =20 mg/min) with the same frequency as oral products;switch patient to oral products as soon as possible Rectal: Dilute syrup 1:1 with water for use as a retention enema; loading dose: 17-20 mg/kg one time; maintenance: 10-15 mg/kg/dose every 8 hours Not dialyzable (0% to 5%) Dosing adjustment/comments in hepatic impairment: Reduce dose


Patient Information :

When used to treat generalized seizures, patient instructions are determined by patientís condition and ability to understand. Oral: Take as directed; do not alter dose or timing of medication. Do not increase dose or take more than recommended. Do not crush or chew capsule or enteric-coated pill. While using this medication, do not use alcohol and other prescription or OTC medications (especially pain medications, sedatives, antihistamines, or

hypnotics) without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Diabetics should monitor serum glucose closely (valproic acid will alter results of urine ketones). Report alterations in menstrual cycle; abdominal cramps, unresolved diarrhea, vomiting, or constipation; skin rash; unusual bruising or bleeding; blood in urine, stool or vomitus; malaise; weakness; facial swelling; yellowing of skin or eyes; excessive sedation; or restlessness. Pregnancy precautions: Do not get pregnant while taking this medication; use appropriate barrier contraceptive measures.

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0098525 

IM LIVING IN PHILIPPINES. IN METRO MANILA.HOW CAN I BUY THE AN Amitriptyline HERE.? BUT I CANT BUY IT ONLINE
PLS MESSAGE ME IN MY YAHOO IF ANYONE CAN HELP ME
[email protected]

ricci 

can ferrous sulfate overdose be a cause of memory loss or memory degeneration? i know a friend who overdosed himself with more than 50 capsules of United Home ferrous sulfate in a suicidal attempt. Luckily, he's still alive. he storied to me that after few hours of overdosing FeSO4, he vomited and his stool became very dark brown. After that, his life became normal although he's complaining that most of the times, he suddenly forgets facts/information which he already memorized or been too long to know such info. There are also times that when he's too much drunk, he can't remember any detail or any information of things that have transpired when he became drunk. i hope you can help me.

ASHISHMARBADE 

I HAVE KNOW VERY GOOD INFORMATION FROM YOUR WEB PORTAL. ASHISH

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