Successful therapy with sucralfate should not be expected to alter the posthealing frequency of recurrence or the severity of duodenal ulceration; use with caution in patients with chronic renal failure who have an impaired excretion of absorbed aluminum. Because of the potential for sucralfate to alter the absorption of some drugs, separate administration (take other
medication 2 hours before sucralfate) should be considered when alterations in bioavailability are believed to be critical
Decreased effect: Digoxin, phenytoin (hydantoins), warfarin, ketoconazole, quinidine, ciprofloxacin, norfloxacin (quinolones), tetracycline, theophylline; because of the potential for sucralfate to alter the absorption of some drugs, separate administration (take other medications 2 hours before sucralfate) should be considered when alterations in bioavailability are believed to be critical
Over Dose / Poisoning :
Toxicity is minimal, may cause constipation
Dosage :
Children: Dose not established, doses of 40-80 mg/kg/day divided every 6 hours have been used Stomatitis: 2.5-5 mL (1 g/10 mL suspension), swish and spit or swish and swallow 4 times/day
Adults: Stress ulcer prophylaxis: 1 g 4 times/day Stress ulcer treatment: 1 g every 4 hours Duodenal ulcer: Treatment: 1 g 4 times/day on an empty stomach and at bedtime for 4-8 weeks, or alternatively 2 g twice daily; treatment is recommended for 4-8 weeks in adults, the elderly may require 12 weeks Maintenance: Prophylaxis: 1 g twice daily Stomatitis: 1 g/10 mL suspension, swish and spit or swish and swallow 4 times/day Dosage comment in renal impairment: Aluminum salt is minimally absorbed (<5%), however, may accumulate in renal failure
Patient Information :
Take before meals or on an empty stomach; do not take antacids 30 minutes before or after taking sucralfate
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