Giving oral dose at 6 PM may be better than 10 PM bedtime, the highest acid production usually starts at approximately 7 PM, thus giving at 6 PM controls acid secretion better
children: Oral: 1.25-2.5 mg/kg/dose every 12 hours; maximum: 300 mg/day I.M., I.V.: 0.75-1.5 mg/kg/dose every 6-8 hours, maximum daily dose: 400 mg Continuous infusion: 0.1-0.25 mg/kg/hour (preferred for stress ulcer

prophylaxis in patients with concurrent maintenance I.V.s or TPNs) Adults: Short-term treatment of ulceration: 150 mg/dose twice daily or 300 mg at bedtime Prophylaxis of recurrent duodenal ulcer: Oral: 150 mg at bedtime Gastric hypersecretory conditions: Oral: 150 mg twice daily, up to 600mg/day I.M., I.V.: 50 mg/dose every 6-8 hours (dose not to exceed 400 mg/day) I.V.: 50 mg/dose IVPB every 6-8 hours (dose not to exceed 400 mg/day) or Continuous I.V. infusion: Initial: 50 mg IVPB, followed by 6.25 mg/hour titrated to gastric pH >4.0 for prophylaxis or >7.0 for treatment; continuous I.V. infusion is preferred in patients with active bleeding Gastric hypersecretory conditions: Doses up to 2.5 mg/kg/hour (220 mg/hour) have been used Dosing adjustment in renal impairment: Clcr 10-50 mL/minute: Administer at 75% of normal dose or administer every 18-24 hours Clcr <10 mL/minute: Administer at 50% of normal dose or administer every 18-24 hours Hemodialysis: Slightly dialyzable (5% to 20%) Dosing adjustment/comments in hepatic disease: Unchanged ADMINISTRATION – Ranitidine injection may be administered I.M. or I.V., I.M.: Injection is given undiluted I.V. must be diluted and may be administered IVP or IVPB or continuous I.V. infusion. IVP: Ranitidine (usually 50 mg) should be diluted to a total of 20 mL with NS or D5W and administered over at least 5 minutes. IVPB: administer over 15-20 minutes. Continuous I.V. infusion: Administer at 6.25 mg/hour and titrate dosage based on gastric pH by continuous infusion over 24 hours