Antispasmodic for neurogenic bladder (urgency, frequency, urge incontinence) and uninhibited bladder.

Use with caution in patients with urinary tract obstruction, angle-closure glaucoma, hyperthyroidism, reflux esophagitis, heart disease, hepatic or renal disease, prostatic hypertrophy, autonomic neuropathy, ulcerative colitis (may cause ileus and toxic megacolon), hypertension, hiatal hernia. Caution should be used in elderly due to anticholinergic activity (eg, confusion, constipation, blurred vision, and tachycardia).

Glaucoma, myasthenia gravis, partial or complete GI obstruction, GU obstruction, ulcerative colitis, hypersensitivity to drug or specific component, intestinal atony, megacolon, toxic megacolon

>10%: Central nervous system: Drowsiness Gastrointestinal: Xerostomia, constipation Miscellaneous: Diaphoresis (decreased) 1% to 10%: Cardiovascular:

Increased toxicity: Additive sedation with CNS depressants and alcohol Additive anticholinergic effects with antihistamines and anticholinergic agents

Over Dose / Poisoning : Symptoms of overdose include hypotension, circulatory failure, psychotic behavior, flushing, respiratory failure, paralysis, tremor, irritability, seizures, delirium, hallucinations, coma

Symptomatic and supportive treatment; induce emesis or perform gastric lavage followed by charcoal and a cathartic; physostigmine may be required; treat hyperpyrexia with cooling techniques (ice bags, cold applications, alcohol sponges)

Children: 1-5 years: 0.2 mg/kg/dose 2-4 times/day >5 years: 5 mg twice daily, up to 5 mg 4 times/day maximum
Adults: 5 mg 2-3 times/day up to 5 mg 4 times/day maximum
Extended release: Initial: 5 mg once daily, may increase in 5-10 mg increments; maximum: 30 mg daily Elderly: 2.5-5 mg twice daily; increase by 2.5 mg increments every 1-2 days

Take prescribed dose preferably on an empty stomach (1 hour before or 2 hours after meals). You may experience dizziness, lightheadedness, or drowsiness (use caution when driving or engaging in tasks requiring

alertness until response to drug is known); dry mouth or changes in appetite (small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help);constipation (frequent exercise or increased dietary fiber, fruit, and fluid or stool softener may help); decreased sexual ability (reversible with discontinuance of drug); decreased sweating (use caution in hot weather, avoid extreme exercise or activity). Report rapid heartbeat, palpitations, or chest pain; difficulty voiding; or vision changes. Swallow extended-release tablets whole, do not chew or crush. Breast-feeding precautions: Do not breast-feed.