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 Medindia » Medical Education » Distance Education » Omeprazole
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PHARMA

Omeprazole

Omeprazole - Biocid, Losec, Metaloc, Nilsec, Ocid, Omecid, Omepral, Omepraz, Omez, Wincid,
Use:

Short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer.

Pregnancy & Lactation :
Risk Factor - C
Warnings & Precautions:

In long-term (2-year) studies in rats, omeprazole produced a dose-related increase in gastric carcinoid tumors. While available endoscopic evaluations and histologic examinations of biopsy specimens from human stomachs have not detected a risk from short-term exposure to omeprazole, further human data on the effect of sustained hypochlorhydria and hypergastrinemia are

needed to rule out the possibility of an increased risk for the development of tumors in humans receiving long-term therapy. Bioavailability may be increased in the elderly.
Contraindication:

Known hypersensitivity to omeprazole

Adverse Reactions :

1% to 10%: Cardiovascular: Angina, tachycardia, bradycardia, edema Central nervous system: Headache (7%), dizziness; Dermatologic: Rash, urticaria, pruritus, dry skin; Gastrointestinal: Diarrhea, nausea, abdominal pain, vomiting, constipation, anorexia, irritable colon, fecal discoloration, esophageal candidiasis, xerostomia, abnormal taste;

Genitourinary: Testicular pain, urinary tract infection, polyuria; Neuromuscular & skeletal: Back pain, muscle cramps, myalgia, arthralgia, leg pain, weakness occurred in more frequently than 1% of patients; Renal: Pyuria, proteinuria, hematuria, glycosuria; Respiratory: Cough.
< 1 % : Chest pain, fever, fatigue, malaise, apathy, somnolence, nervousness, anxiety, pain, abdominal swelling


Interactions :

Decreased effect: ketoconazole; itraconazole.
Increased toxicity: Diazepam may increase half-life; increased digoxin, increased phenytoin, increased warfarin.


Over Dose / Poisoning :

Symptoms of overdose include hypothermia, sedation, convulsions, decreased respiratory rate.
Treatment is supportive; not dialyzable.


Dosage :

Adults: Oral: Active duodenal ulcer: 20 mg/day for 4-8 weeks. GERD or severe erosive esophagitis: 20 mg/day for 4-8 weeks Pathological hypersecretory conditions: 60 mg once daily to start; doses up to 120 mg 3 times/day have been administered; administer daily doses >80 mg in divided doses Helicobacter pylori:

Combination therapy with bismuth subsalicylate, tetracycline, clarithromycin, and H2-antagonist; or with clarithromycin. Adult dose: Oral: 20 mg twice daily. Gastric ulcers: 40 mg/day for 4-8 weeks


Patient Information :

Take before eating; do not chew, crush, or open capsule



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Member Comments ( 3 )
IM LIVING IN PHILIPPINES. IN METRO MANILA.HOW CAN I BUY THE AN Amitriptyline HERE.? BUT I CANT BUY IT ONLINE
PLS MESSAGE ME IN MY YAHOO IF ANYONE CAN HELP ME
TOM_AB1980@YAHOO.COM

(Posted by 0098525, Philippines Date : 11/11/2010 )
can ferrous sulfate overdose be a cause of memory loss or memory degeneration? i know a friend who overdosed himself with more than 50 capsules of United Home ferrous sulfate in a suicidal attempt. Luckily, he's still alive. he storied to me that after few hours of overdosing FeSO4, he vomited and his stool became very dark brown. After that, his life became normal although he's complaining that most of the times, he suddenly forgets facts/information which he already memorized or been too long to know such info. There are also times that when he's too much drunk, he can't remember any detail or any information of things that have transpired when he became drunk. i hope you can help me.
(Posted by ricci, Philippines Date : 9/13/2010 )
I HAVE KNOW VERY GOOD INFORMATION FROM YOUR WEB PORTAL. ASHISH
(Posted by ASHISHMARBADE, India Date : 7/21/2009 )